Monoamine receptor

The serotonin 5-HT_1B receptor as an example of a monoamine receptor.^[1] Its crystallographic structure in ribbon representation.

A monoamine receptor is a receptor for the monoamine neurotransmitters and/or trace amines, endogenous small-molecule signaling molecules with a monoamine structure. The monoamine receptors are almost all G protein-coupled receptors, with the serotonin 5-HT₃ receptor being a notable exception as a ligand-gated ion channel.^[1] Monoamine receptors are the biological targets of many drugs; such drugs may be referred to as "monoaminergic".

List of receptors[]

Monoamine receptors include the following classes:

Adrenergic receptors – bound by epinephrine (adrenaline) and norepinephrine (noradrenaline)
Dopamine receptors – bound by dopamine
Histamine receptors – bound by histamine
Melatonin receptors – bound by melatonin
Serotonin receptors – bound by serotonin (5-HT)
Trace amine-associated receptors – bound by trace amines, thyronamines, monoamine neurotransmitters (TAAR1 only), and trimethylamine (TAAR5 only)

References[]

^ ^a ^b Martin, Andres; Scahill, Lawrence; Kratochvil, Christopher (14 December 2010). Pediatric Psychopharmacology. Oxford University Press. p. 31. ISBN 9780199842667. Retrieved 27 January 2017. The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.

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[MartinScahill2010-1] Martin, Andres; Scahill, Lawrence; Kratochvil, Christopher (14 December 2010). Pediatric Psychopharmacology. Oxford University Press. p. 31. ISBN 9780199842667. Retrieved 27 January 2017. The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.

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