Nucleus reuniens

Nucleus reuniens
Nucleus reuniens
Details
Identifiers
Latin	Nucleus reuniens
NeuroNames	309
NeuroLex ID	birnlex_770
TA98	A14.1.08.632
FMA	62153
	Anatomical terms of neuroanatomy [edit on Wikidata]

The nucleus reuniens is a component of the thalamic midline nuclear group.^[1] In the human brain, it is located in the interthalamic adhesion (massa intermedia).^[2]

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.^[3] It sends projections to the medial prefrontal cortex, the hippocampus, and the entorhinal cortex,^[4]^[5] although there exist sparse connections to many of the afferent structures as well.^[6]

The prefrontal cortical-hippocampal connection allows it to regulate neural traffic between them with changes in attentiveness,^[7] as well as contribute to associative learning,^[8] spatial route planning,^[9] resilience to stress^[10] and memory generalization.^[11]

References[]

^ Griffin, Amy L. (2015-01-01). "Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory". Frontiers in Systems Neuroscience. 9: 29. doi:10.3389/fnsys.2015.00029. ISSN 1662-5137. PMC 4354269. PMID 25805977.
^ Carpenter, Malcolm; Sutin, Jerome (1983). Human Neuroanatomy. Baltimore: Williams & Wilkins. pp. 504–510. ISBN 978-0-683-01461-7.
^ McKenna, J. T.; Vertes, R. P. (2004). "Afferent projections to nucleus reuniens of the thalamus". The Journal of Comparative Neurology. 480 (2): 115–142. doi:10.1002/cne.20342. PMID 15514932. S2CID 9284778.
^ Wouterlood, F. G.; Saldana, E.; Witter, M. P. (1990). "Projection from the nucleus reuniens thalami to the hippocampal region: Light and electron microscopic tracing study in the rat with the anterograde tracerPhaseolus vulgaris-leucoagglutinin". The Journal of Comparative Neurology. 296 (2): 179–203. doi:10.1002/cne.902960202. PMID 2358531. S2CID 24568442.
^ Vertes, R. P. (2006). "Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat". Neuroscience. 142 (1): 1–20. doi:10.1016/j.neuroscience.2006.06.027. PMID 16887277. S2CID 5591335.
^ Herkenham, M. (1978). "The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat". The Journal of Comparative Neurology. 177 (4): 589–610. doi:10.1002/cne.901770405. PMID 624792. S2CID 7535058.
^ Vertes, R. P.; Hoover, W. B.; Szigeti-Buck, K.; Leranth, C. (2007). "Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus". Brain Research Bulletin. 71 (6): 601–609. doi:10.1016/j.brainresbull.2006.12.002. PMC 4997812. PMID 17292803.
^ Eleore, L.; López-Ramos, J. C.; Guerra-Narbona, R.; Delgado-García, J. M. (2011). Izquierdo, Ivan (ed.). "Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning". PLOS ONE. 6 (8): e23538. Bibcode:2011PLoSO...623538E. doi:10.1371/journal.pone.0023538. PMC 3156136. PMID 21858159.
^ Ito, H. T.; Zhang, S. J.; Witter, M. P.; Moser, E. I.; Moser, M. B. (2015). "A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation". Nature. 522 (7554): 50–5. Bibcode:2015Natur.522...50I. doi:10.1038/nature14396. hdl:11250/2493579. PMID 26017312. S2CID 205243449.
^ Kafetzopoulos, V.; Kokras, N.; Sotiropoulos, I.; Oliveira, J. F.; Leite-Almeida, H.; Vasalou, A.; Sardinha, V. M.; Papadopoulou-Daifoti, Z.; Almeida, O. F. X. (2017-04-11). "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry. 23 (3): 579–586. doi:10.1038/mp.2017.55. ISSN 1476-5578. PMC 5822458. PMID 28397837.
^ Xu, W.; Sudhof, T. C. (14 March 2013). "A Neural Circuit for Memory Specificity and Generalization". Science. 339 (6125): 1290–1295. Bibcode:2013Sci...339.1290X. doi:10.1126/science.1229534. PMC 3651700. PMID 23493706.

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[1] Griffin, Amy L. (2015-01-01). "Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory". Frontiers in Systems Neuroscience. 9: 29. doi:10.3389/fnsys.2015.00029. ISSN 1662-5137. PMC 4354269. PMID 25805977.

[2] Carpenter, Malcolm; Sutin, Jerome (1983). Human Neuroanatomy. Baltimore: Williams & Wilkins. pp. 504–510. ISBN 978-0-683-01461-7.

[3] McKenna, J. T.; Vertes, R. P. (2004). "Afferent projections to nucleus reuniens of the thalamus". The Journal of Comparative Neurology. 480 (2): 115–142. doi:10.1002/cne.20342. PMID 15514932. S2CID 9284778.

[4] Wouterlood, F. G.; Saldana, E.; Witter, M. P. (1990). "Projection from the nucleus reuniens thalami to the hippocampal region: Light and electron microscopic tracing study in the rat with the anterograde tracerPhaseolus vulgaris-leucoagglutinin". The Journal of Comparative Neurology. 296 (2): 179–203. doi:10.1002/cne.902960202. PMID 2358531. S2CID 24568442.

[5] Vertes, R. P. (2006). "Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat". Neuroscience. 142 (1): 1–20. doi:10.1016/j.neuroscience.2006.06.027. PMID 16887277. S2CID 5591335.

[6] Herkenham, M. (1978). "The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat". The Journal of Comparative Neurology. 177 (4): 589–610. doi:10.1002/cne.901770405. PMID 624792. S2CID 7535058.

[7] Vertes, R. P.; Hoover, W. B.; Szigeti-Buck, K.; Leranth, C. (2007). "Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus". Brain Research Bulletin. 71 (6): 601–609. doi:10.1016/j.brainresbull.2006.12.002. PMC 4997812. PMID 17292803.

[8] Eleore, L.; López-Ramos, J. C.; Guerra-Narbona, R.; Delgado-García, J. M. (2011). Izquierdo, Ivan (ed.). "Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning". PLOS ONE. 6 (8): e23538. Bibcode:2011PLoSO...623538E. doi:10.1371/journal.pone.0023538. PMC 3156136. PMID 21858159.

[9] Ito, H. T.; Zhang, S. J.; Witter, M. P.; Moser, E. I.; Moser, M. B. (2015). "A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation". Nature. 522 (7554): 50–5. Bibcode:2015Natur.522...50I. doi:10.1038/nature14396. hdl:11250/2493579. PMID 26017312. S2CID 205243449.

[10] Kafetzopoulos, V.; Kokras, N.; Sotiropoulos, I.; Oliveira, J. F.; Leite-Almeida, H.; Vasalou, A.; Sardinha, V. M.; Papadopoulou-Daifoti, Z.; Almeida, O. F. X. (2017-04-11). "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry. 23 (3): 579–586. doi:10.1038/mp.2017.55. ISSN 1476-5578. PMC 5822458. PMID 28397837.

[Xu_2013-11] Xu, W.; Sudhof, T. C. (14 March 2013). "A Neural Circuit for Memory Specificity and Generalization". Science. 339 (6125): 1290–1295. Bibcode:2013Sci...339.1290X. doi:10.1126/science.1229534. PMC 3651700. PMID 23493706.

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