Otoyol 52 (English: Motorway 52), abbreviated as O-52, a.k.a. Adana-Şanlıurfa Otoyolu (English: Adana-Şanlıurfa Motorway), is a tollmotorway in the regions of Mediterranean and Southeastern Anatolia in Turkey, connecting the cities Adana and Şanlıurfa. The motorway is part of European route E90 and Asian Highway 84. The O-52 starts from the eastern terminus of The O-51, runs eastward through Osmaniye, Gaziantep and terminates east of Şanlıurfa. The O-52 is currently the second longest Motorway in Turkey being only 5 km shorter than the O-4.
E 90 / AH84
D.400 in Haliliye, Şanlıurfa
in 
O-51 to Mersin
— Pınarbaşı
— Ceyhan
O-53 — İskenderun
D.825 — Nurdağı
— Narlı
O-54 (Gaziantep Bltwy) — 
— Şanlıurfa
