Sorivudine

Sorivudine
Clinical data
Trade names	Usevir, Brovavir
Other names	BV-araU, Bromovinyl araU, 5-Bromovinyl-araU, 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Routes of; administration	Oral
ATC code	none;
Pharmacokinetic data
Metabolism	Viral thymidine kinase
Excretion	Kidney
Identifiers
	show IUPAC name
CAS Number	77181-69-2 ;
PubChem CID	5282192;
ChemSpider	4445384 ;
UNII	C7VOZ162LV;
KEGG	D01734 ;
ChEMBL	ChEMBL375035 ;
CompTox Dashboard (EPA)	DTXSID6057827 ;
Chemical and physical data
Formula	C11H13BrN2O6
Molar mass	349.137 g·mol−1
3D model (JSmol)	Interactive image;
	show SMILES
	show InChI
	(what is this?)

Sorivudine (INN), is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir (, Eisai) and Brovavir (BMS). It is used for the treatment of varicella zoster virus infections.^[1]

Pharmacology[]

Feature[]

First-line^{[citation needed]} treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
Undergoes gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted in urine.

Mechanism of action[]

Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.

Microbiology[]

Sorivudine is active against most species in the herpesvirus family.

Herpes simplex virus type I (HSV-1)
Varicella zoster virus (VZV)
Epstein-Barr virus (EBV)

Interactions[]

Sorivudine interacts strongly and in some cases lethally with fluorouracil (5-FU), its prodrugs and related substances. This is based on the metabolite bromovinyluracil (BVU), which irreversibly inhibits the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. The closely related drug brivudine has the same interaction.^[2]

Bromovinyluracil (BVU)

References[]

^ Whitley RJ (1996). "Sorivudine: a potent inhibitor of varicella zoster virus replication". Advances in Experimental Medicine and Biology. 394: 41–4. doi:10.1007/978-1-4757-9209-6_5. PMID 8815706.
^ "UAW – Aus Fehlern lernen - Potenziell tödlich verlaufende Wechselwirkung zwischen Brivudin (Zostex) und 5-Fluoropyrimidinen" (PDF). Deutsches Ärzteblatt (in German). 103 (27). 7 July 2006.

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[pmid8815706-1] Whitley RJ (1996). "Sorivudine: a potent inhibitor of varicella zoster virus replication". Advances in Experimental Medicine and Biology. 394: 41–4. doi:10.1007/978-1-4757-9209-6_5. PMID 8815706.

[2] "UAW – Aus Fehlern lernen - Potenziell tödlich verlaufende Wechselwirkung zwischen Brivudin (Zostex) und 5-Fluoropyrimidinen" (PDF). Deutsches Ärzteblatt (in German). 103 (27). 7 July 2006.

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