15α-Hydroxyestradiol
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Preferred IUPAC name
(1S,3S,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,3,7-triol | |
Other names
15α-OH-E2; 15α-Hydroxy-17β-estradiol; Estra-1,3,5(10)-triene-3,15α,17β-triol; 3,15α,17β-Trihydroxyestra-1,3,5(10)-triene
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Chemical formula
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C18H24O3 |
Molar mass | 288.387 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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15α-Hydroxyestradiol (15α-OH-E2) is an endogenous estrogen which occurs during pregnancy.[1][2][3] It is structurally related to estriol (16α-hydroxyestradiol) and estetrol (15α-hydroxyestriol or 15α,16α-dihydroxyestradiol).
References[]
- ^ Lisboa BP, Goebelsmann U, Diczfalusy E (March 1967). "Isolation of 15-alpha-hydroxyoestradiol from human pregnancy urine". Acta Endocrinol. 54 (3): 467–72. doi:10.1530/acta.0.0540467. PMID 6071364.
- ^ Jirku H, Kadner S, Levitz M (October 1972). "Metabolism of 15alpha-hydroxyestradiol in human pregnancy". J. Clin. Endocrinol. Metab. 35 (4): 522–34. doi:10.1210/jcem-35-4-522. PMID 4559652.
- ^ Lee AJ, Kosh JW, Conney AH, Zhu BT (August 2001). "Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5". J. Pharmacol. Exp. Ther. 298 (2): 420–32. PMID 11454902.
Categories:
- Estranes
- Estrogens
- Hormones of the hypothalamus-pituitary-gonad axis
- Hormones of the pregnant female
- Phenols
- Triols
- Steroid stubs