Estromustine
From Wikipedia, the free encyclopedia
Not to be confused with Estramustine phosphate or Estramustine.
![]() | |
Clinical data | |
---|---|
Other names | EoM; Leo 271 f; Estrone 17β-3-N-bis(2-chloroethyl)carbamate; Estrone–cytostatic complex |
Drug class | Chemotherapeutic agent; Estrogen; Estrogen ester |
Pharmacokinetic data | |
Elimination half-life | 14 hours[1] |
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C23H29Cl2NO3 |
Molar mass | 438.39 g·mol−1 |
3D model (JSmol) | |
SMILES
| |
InChI
|
Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex,[2] is a major active metabolite of the cystotatic antineoplastic agent and estrogen estramustine phosphate, a medication used in the treatment of prostate cancer.[1][3]
See also[]
- List of hormonal cytostatic antineoplastic agents
- List of estrogen esters § Estradiol esters
References[]
- ^ a b Chabner BA, Longo DL (7 December 2011). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 252–. ISBN 978-1-4511-4820-6.
- ^ Yamanaka H, Kitaura K, Imai K, Yuasa H, Nakai K, Matsumura Y, Uehara H, Shida K (1981). "In vivo studies of 3H-estramustine in castrated male rat". Acta Urologica Japonica. 27 (3): 243–50.
- ^ Medical Subject Headings: Supplementary chemical records. The Library. 1993. p. 684.
Estrogen receptor modulators | |||||||
---|---|---|---|---|---|---|---|
ER |
| ||||||
GPER |
| ||||||
|
Androgen receptor modulators | |||||||
---|---|---|---|---|---|---|---|
AR |
| ||||||
GPRC6A |
| ||||||
|
![]() | This article about a steroid is a stub. You can help Wikipedia by . |
- v
- t
![]() | This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by . |
- v
- t
Retrieved from ""
Categories:
- Abandoned drugs
- Antiandrogens
- Antigonadotropins
- Antineoplastic drugs
- Carbamates
- Chloroethyl compounds
- Estradiol esters
- Estranes
- Estrogens
- Human drug metabolites
- Ketones
- Mitotic inhibitors
- Nitrogen mustards
- Organochlorides
- Phenol esters
- Steroid stubs
- Antineoplastic and immunomodulating drug stubs
Hidden categories:
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- All stub articles