Aglepristone Trade names Alizin Other names RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one Drug class Antiprogestogen ; Antiglucocorticoid ATC code
(8S ,11R ,13S ,14S ,17R )-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z )-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a ]phenanthren-3-one
CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL ECHA InfoCard 100.211.372 Formula C 29 H 37 N O 2 Molar mass −1 3D model (JSmol )
C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N
Aglepristone (INN Alizin ; former developmental code names RU-46534 , RU-534 ) is a synthetic , steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine .[1] [2] [3] abortifacient in pregnant animals.[1] [3] [4] antiglucocorticoid activity.[5] [6]
See also [ ] References [ ]
^ a b John D. Bonagura; David C. Twedt (1 December 2013). Kirk's Current Veterinary Therapy XV ISBN 978-0-323-22762-9 ^ E. James Squires (2010). Applied Animal Endocrinology ISBN 978-1-84593-755-3 ^ a b Mark G. Papich (3 November 2010). Saunders Handbook of Veterinary Drugs: Small and Large Animal ISBN 978-1-4377-0192-0 ^ Patrick W. Concannon (2001). Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000 ISBN 978-0-906545-37-9 ^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, Cabrera F, Gracia A (2011). "Induction of parturition with aglepristone in the Majorera goat". Reprod. Domest. Anim . 46 (5): 882–8. doi :10.1111/j.1439-0531.2011.01759.x . PMID 21320179 . ^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology . 69 (4): 399–407. doi :10.1016/j.theriogenology.2007.10.008 . PMID 18054071 .
Progestogens and antiprogestogens
Progestogens progestins )
PR agonists
Retroprogesterone derivatives: Dydrogesterone Trengestone Testosterone derivatives: Estranes: Danazol Dimethisterone Ethisterone 19-Nortestosterone derivatives: Estranes: Allylestrenol Altrenogest Dienogest Etynodiol diacetate Lynestrenol Norethisterone (norethindrone) # Norethisterone acetate Norethisterone enanthate Noretynodrel Norgesterone Norgestrienone Normethandrone (methylestrenolone) Norvinisterone Oxendolone Quingestanol acetate Tibolone ; Gonanes: Desogestrel Etonogestrel Gestodene Gestrinone Levonorgestrel # Norelgestromin Norgestimate Norgestrel Spirolactone derivatives: Drospirenone
Antiprogestogens
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
See also
Progesterone receptor modulators Androgens and antiandrogens Estrogens and antiestrogens List of progestogens
GR
Agonists MixedSEGRMs
Dagrocorat Fosdagrocorat Mapracorat Antagonists Others
See also
Receptor/signaling modulators Glucocorticoids and antiglucocorticoids Mineralocorticoid receptor modulators List of corticosteroids
PR
Agonists
Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone 6,6-Difluoronorethisterone acetate 17α-Allyl-19-nortestosterone Allylestrenol Altrenogest Chloroethynylnorgestrel Cingestol Danazol Desogestrel Dienogest Ethinylandrostenediol
Ethisterone Ethynerone Etonogestrel Etynodiol Etynodiol diacetate Gestodene Gestrinone Levonorgestrel Levonorgestrel esters (e.g., levonorgestrel butanoate )Lynestrenol Lynestrenol phenylpropionate Metynodiol Metynodiol diacetate Norelgestromin Norethisterone (norethindrone) Norethisterone esters (e.g., norethisterone acetate , norethisterone enanthate )Noretynodrel Norgesterone Norgestimate Norgestrel Norgestrienone Norvinisterone Oxendolone Quingestanol Quingestanol acetate Tibolone Tigestol Tosagestin ; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone 11β-Methyl-19-nortestosterone dodecylcarbonate 19-Nor-5-androstenediol 19-Nor-5-androstenedione 19-Nordehydroepiandrosterone Bolandiol Bolandiol dipropionate Bolandione Dimethisterone Dienedione Dienolone Dimethandrolone Dimethandrolone buciclate Dimethandrolone dodecylcarbonate Dimethandrolone undecanoate Dimethyldienolone Dimethyltrienolone Ethyldienolone Ethylestrenol (ethylnandrol) Methyldienolone Metribolone (R-1881) Methoxydienone (methoxygonadiene) Mibolerone Nandrolone Nandrolone esters (e.g., nandrolone decanoate , nandrolone phenylpropionate )Norethandrolone Normethandrone (methylestrenolone, normethandrolone, normethisterone) RU-2309 Tetrahydrogestrinone Trenbolone (trienolone) Trenbolone esters (e.g., trenbolone acetate , trenbolone enanthate )Trendione Trestolone Trestolone acetate Spirolactone derivatives: Canrenoic acid Canrenone Drospirenone Mespirenone Potassium canrenoate Prorenone SC-5233 (spirolactone) SC-8109 Spironolactone Spirorenone MixedSPRMs
Nonsteroidal: Apigenin Kaempferol Naringenin Syringic acid Antagonists
Nonsteroidal: Darolutamide Valproic acid
mPR PAQR
See also
Receptor/signaling modulators Progestogens and antiprogestogens Androgen receptor modulators Estrogen receptor modulators List of progestogens
Other sex hormones and modulators of the genital system (G03X )
Antigonadotropins (G03XA)
Danazol Gestrinone Anti-Pmsg Antiprogestogens (G03XB)Selective estrogen (G03XC)Others (G03XX)
