Androgen-binding protein

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Structures	Swiss-model
Domains	InterPro

Androgen-binding protein, Sex hormone-binding globulin
Androgen-binding protein, Sex hormone-binding globulin
Identifiers
Symbol	SHBG
Alt. symbols	ABP
NCBI gene	6462
HGNC	10839
OMIM	182205
RefSeq	NM_001040
UniProt	P04278
Other data
Locus	Chr. 17 p13-p12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Androgen-binding protein (ABP) is a glycoprotein (beta-globulin) produced by the Sertoli cells^[1] in the seminiferous tubules^[2] of the testis that binds specifically to testosterone (T), dihydrotestosterone (DHT), and 17-beta-estradiol.

Because ABP binds to T and DHT, these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable spermatogenesis in the seminiferous tubules and sperm maturation in the epididymis.

ABP has the same amino acid sequence as sex hormone-binding globulin (SHBG); the difference is the site of production and the addition of different sugar moieties. ABP contains 403 amino acids, resulting in a molecular weight of 44,533. Its gene is located on chromosome 17.

ABP’s production is regulated under the influence of FSH^[2] on Sertoli cells, enhanced by insulin, retinol, and testosterone.

The human ABP is not to be confused with a mouce secretoglobin of the same name, which is produced in the saliva.

References[]

^ Bardin CW, Musto N, Gunsalus G, Kotite N, Cheng SL, Larrea F, Becker R (1981). "Extracellular androgen binding proteins". Annual Review of Physiology. 43: 189–98. doi:10.1146/annurev.ph.43.030181.001201. PMID 7011179.
^ ^a ^b Hansson V, Weddington SC, French FS, McLean W, Smith A, Nayfeh SN, Ritzén EM, Hagenäs L (September 1976). "Secretion and role of androgen-binding proteins in the testis and epididymis". Journal of Reproduction and Fertility. Supplement (24 suppl): 17–33. PMID 1069850.

External links[]

Androgen-Binding+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
Ensembl Gene ref Protein ref

[Bardin_1981-1] Bardin CW, Musto N, Gunsalus G, Kotite N, Cheng SL, Larrea F, Becker R (1981). "Extracellular androgen binding proteins". Annual Review of Physiology. 43: 189–98. doi:10.1146/annurev.ph.43.030181.001201. PMID 7011179.

[Hansson_1976-2] Hansson V, Weddington SC, French FS, McLean W, Smith A, Nayfeh SN, Ritzén EM, Hagenäs L (September 1976). "Secretion and role of androgen-binding proteins in the testis and epididymis". Journal of Reproduction and Fertility. Supplement (24 suppl): 17–33. PMID 1069850.

[1]

[2]

v t Proteins: carrier proteins
Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7
Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin
Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor
Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin
Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin
Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

Androgen-binding protein

See also[]

References[]

External links[]