COVID-19 vaccination in Romania

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COVID-19 vaccination in Romania
Date27 December 2020–present
LocationNationwide
CauseCOVID-19 pandemic in Romania
Organised byGovernment of Romania
Participants4,734,911 people vaccinated with at least one dose (1 July 2021)
24.51%
4,544,863 people fully vaccinated (1 July 2021)
23.55%
Websitevaccinare-covid.gov.ro

COVID-19 vaccination in Romania started on 27 December 2020. It was announced that the process would be divided into three phases. Medical personnel would be vaccinated first (first phase), followed by the population at risk (second phase), and finally by the rest of the population (third phase).[1] Vaccination was declared free and non-mandatory.[1] As of May 2021, four types of vaccines (Pfizer/BioNTech, Moderna, Oxford/AstraZeneca, and Janssen) were authorized to be used in Romania.[2] This is the largest vaccination campaign in the modern history of Romania.[3]

According to Prime Minister Florin Cîțu, Romania aims to vaccinate 10.4 million people (or 70% of the country's population) by the end of September 2021.[4] By the beginning of June, more than 4.4 million people (or 25% of the eligible population aged 12 years and older) had received at least one shot of COVID-19 vaccine in Romania.[5]

Background[]

Responsibility for COVID-19 vaccine deployment[]

The National Coordinating Committee for COVID-19 Vaccination Activities (Romanian: Comitetul Național de Coordonare a Activităților privind Vaccinarea împotriva COVID-19; abbreviated CNCAV) is the inter-ministerial body responsible for developing the national vaccination strategy. It was established on 20 November 2020 by Prime Minister's decree and is subordinated to the General Secretariat of the Government.[6] The first president of the Committee is Valeriu Gheorghiță, doctor at the Central Military Hospital in Bucharest.[7] The Romanian Army and structures from the Ministry of Interior are involved in the distribution and transport of vaccines.[8]

Vaccines on order[]

Vaccine Origin Doses ordered Approval[2] Deployment
Pfizer/BioNTech US/Germany 10 million[9] Green check.svg 21 December 2020 Green check.svg 26 December 2020[10]
Moderna US N/A Green check.svg 6 January 2021 Green check.svg 12 January 2021[11]
Oxford/AstraZeneca UK/Sweden N/A Green check.svg 29 January 2021 Green check.svg 7 February 2021[12]
Janssen Netherlands/Israel 8 million[13] Green check.svg 11 March 2021 Green check.svg 4 May 2021
Novavax US Pending Pending
CureVac Germany Pending Pending
Valneva France Pending Pending
Sanofi/GSK France/UK Pending Pending
Total 85 million[14]

Rollout schedule[]

On 26 December 2020, Ion Cantacuzino Institute in Bucharest received the first symbolic 10,000-dose batch of the Pfizer/BioNTech vaccine.[15] The truck with the first doses of vaccine entered Romania at Nădlac customs the day before in the presence of Raed Arafat, head of the Department for Emergency Situations and Valeriu Gheorghiță, head of the National Coordinating Committee for COVID-19 Vaccination Activities.[16] Vaccination began on 27 December in 10 infectious disease hospitals across the country,[15] with Mihaela Anghel, a nurse at the Matei Balș National Institute for Infectious Diseases in Bucharest, being the first person vaccinated. Anghel was among the personnel that treated the country's first infected person on 27 February of the same year.[17]

On 29 December 2020, Romanian President Klaus Iohannis announced that Romania would help Moldova with a donation of 200,000 doses of COVID-19 vaccine units in the future during his meeting with the Moldovan President Maia Sandu in the country as part of a collaboration project about the COVID-19 pandemic and other topics between the two countries.[18] Iohannis himself was vaccinated on 15 January 2021.[19] The first batch of COVID-19 vaccines destined to be sent to Moldova from Romania, composed of an amount of 20,000 of them, was approved by the Government of Romania on 24 February 2021.[20] Moldova received 21,600 Oxford/AstraZeneca vaccine doses on 27 February from Romania,[21] which started being administered on 2 March.[22][23] Moldova donated 1,810 of these units to the authorities of the unrecognized state of Transnistria on 5 March,[24] which thanked the Romanian state for the help.[25] Other donations from Romania to Moldova took place on 27 March (50,400 doses)[26] and 7 May (100,800 doses).[27]

The first 14,000-dose batch of the Moderna vaccine arrived in the country on 12 January 2021.[11] The vaccine began to be administered on 4 February.[28]

An Oxford/AstraZeneca and Johnson & Johnson vaccination center at ISHO Timișoara

The Oxford/AstraZeneca vaccine arrived in the country on 7 February, the first 81,000 doses being distributed to regional storage centers during the same day.[12] Until 8 March, the vaccination with Oxford/AstraZeneca was intended only for people aged between 18 and 55 years, on the grounds that in the third phase of Oxford/AstraZeneca's clinical trials too few volunteers over 55 were enrolled; on 8 March, CNCAV dropped the age limit for the administration of this vaccine.[29] On 11 March, CNCAV temporarily quarantined 4,257 doses from Oxford/AstraZeneca's ABV2856 batch as an "extreme precautionary measure",[30] hours after Italy banned use of this same batch following the deaths in Sicily of two men who had been inoculated with doses from it.[31] Romania had received 81,600 doses from the ABV2856 batch and administered most of them.[32] Vaccination with these doses was resumed on 19 March[33] after the European Medicines Agency (EMA) declared the Oxford/AstraZeneca vaccine safe for use.[34] In April, EMA found a possible link between the Oxford/AstraZeneca vaccine and very rare cases of unusual blood clots with low platelet counts, although it said its benefits far outweighed the risks and did not announce any restrictions.[35] As of 4 April, EMA received reports of 222 cases of a rare thrombosis affecting the brain or abdomen among some 34 million people in Europe who have received the Oxford/AstraZeneca jab; most occurred in women under 60 within two weeks of vaccination.[35] As a precaution, several European countries limited the use of the Oxford/AstraZeneca vaccine to older age groups. According to Valeriu Gheorghiță, president of CNCAV, no cases of vaccine-related thrombosis had been confirmed in Romania as of 6 April; he did, however, mention seven cases of unrelated thrombosis in seven people vaccinated against COVID-19, four with Pfizer/BioNTech and three with Oxford/AstraZeneca.[36] On 8 April, CNCAV decided to continue the vaccination with Oxford/AstraZeneca for all age groups.[37]

Valeriu Gheorghiță announced on 9 March that the third phase of vaccination will first start rolling out in the localities with an incidence rate of at least 4.5‰.[38] The people from nine localities – seven county seats (Alba Iulia, Baia Mare, Brașov, Cluj-Napoca, Giurgiu, Timișoara and Zalău), a municipality (Petroșani) and a commune (Sânpetru) – could schedule their appointments on the national vaccination platform before the effective start of the third phase,[39] which was set to begin on 15 March.[40] The authorities introduced waiting lists for appointments, however, without the possibility for people to choose the type of vaccine. In order to optimize the distribution of vaccine doses, it was decided that each vaccination center should inoculate only one type of vaccine.[41]

On 11 March, the one-shot Janssen COVID-19 vaccine became the fourth vaccine to be conditionally approved on the EU level,[42] arriving in Romania on 14 April.[43] The 60,000 doses in the first batch remained in storage, as Romanian authorities waited for indications from EMA regarding the safety of the vaccine.[44] In the US, the Centers for Disease Control and Prevention and the Food and Drug Administration recommended a temporary halt on Johnson & Johnson vaccinations in the country after the appearance of six cases of a rare and severe type of blood clot in people inoculated with this vaccine; by mid-April, more than 6.8 million doses of the Janssen vaccine have been administered in the US.[45] EMA finally gave green light to the Janssen vaccine on 20 April,[46] and the first doses began to be distributed to vaccination centers in Romania on 4 May.[citation needed]

In April, family doctors joined the vaccination teams, with first shots being administered in Timiș County.[47] At the beginning of the month, the participation rate among family doctors was about 50–55%.[48] On 17 April, Romania made a new donation to Moldova: 132,000 vaccine units were given to the latter.[49][50][51] In an effort to boost rural access to the vaccine, officials launched on 21 April the first mobile vaccination centers in seven counties; in the first phase, mainly Moderna vaccine was distributed in these centers.[52] On 24 April, the first drive-through vaccination center was inaugurated in the parking lot of Deva Shopping City.[53] Between 23 and 26 April, Timișoara Regional Business Center hosted a three-day non-stop vaccination marathon. In the first such action in the country, 6,722 people were vaccinated by more than 500 volunteers.[54] Other vaccination marathons soon followed in Bucharest, Cluj-Napoca, Târgu Mureș and Iași.[55]

In the first weekend of May, walk-in vaccinations were introduced in all centers in the country, with priority for people over 60.[56] Previously, as Oxford/AstraZeneca vaccine stockpiled throughout the country, only people interested in getting this vaccine were able to show up at the vaccination centers without prior appointment.[57] On 2 June, authorities began immunizing children aged 12 to 15 with the Pfizer/BioNTech vaccine.[58] Previously, on 28 May, EMA issued a recommendation for the authorization of the Pfizer/BioNTech vaccine for this age group.[59] In the first week, almost 9,400 12-to-15-year-olds have received the vaccine, most of them in Bucharest.[60]

Vaccine storage and distribution centers[]

The Ion Cantacuzino Institute in Bucharest and six military hospitals in the country are the centers where the COVID-19 vaccine is stored, as they have freezers with a large capacity that can ensure storage in the required conditions (e.g., cold chains of −80°C).[61]

COVID-19 vaccination in Romania is located in Romania
Ion Cantacuzino Institute Bucharest
Ion Cantacuzino Institute
Bucharest
Iacob Czihac Hospital Iași
Iacob Czihac Hospital
Iași
Constantin Papilian Hospital Cluj-Napoca
Constantin Papilian Hospital
Cluj-Napoca
Alexandru Gafencu Hospital Constanța
Alexandru Gafencu Hospital
Constanța
Ștefan Odobleja Hospital Craiova
Ștefan Odobleja Hospital
Craiova
Queen Marie Hospital Brașov
Queen Marie Hospital
Brașov
Victor Popescu Hospital Timișoara
Victor Popescu Hospital
Timișoara
Vaccine storage and distribution centers[62]

Vaccine priority groups[]

Vaccination against COVID-19 in Romania is carried out in three phases, in which priority is given to medical staff, people over 65, people with chronic diseases, people with disabilities, homeless people and essential workers (lawmakers, military personnel, magistrates, teachers, commercial workers, etc.).[63]

Phase Priority groups Number eligible (estimated)
I health and social workers 160,000[64]
II high-risk population 5 million[65]
essential workers 1.5 million[66]
III general population

In early March, the Ministry of Health began publishing official data on vaccines administered at each center in the country on the government's open data portal. Data from 27 December 2020 to 5 March 2021 revealed cases of nepotism regarding the vaccination of military personnel and over 7,000 vaccinations ahead of priority groups.[67] Apart from these, local news agencies reported numerous instances of queue-jumping occurring throughout the Romanian healthcare system, as waiting lists were vulnerable to corruption.[68]

Vaccination centers[]

Before the official start of the vaccination campaign, the Ministry of Health identified 899 vaccination centers throughout the country: 302 in health units for the immunization of medical staff and 597 in other spaces for phases II and III.[69] 583 of them were operational by 30 January 2021.[70] As of 9 March 2021, before the start of the largest phase of the vaccination campaign, 678 vaccination centers with 990 flows were active in the country; according to Valeriu Gheorghiță, the total number of vaccination centers would be 1,137.[71]

Adverse reaction reporting[]

As of 10 June 2021, adverse reactions were reported in 16,344 vaccinated people (0.194% or 1.94 reactions at 1,000 doses administered).[72] Most of them were general reactions (fever, headache, myalgia, asthenia, urticaria, etc.).[72] Only six severe allergic reactions were reported as of 10 June 2021.[73] The median age of people who reported adverse reactions was 37; 63% of them were female.[74] By manufacturer, most adverse reactions have been reported in people vaccinated with Oxford/AstraZeneca (0.74% of the total number of doses administered), followed by Moderna (0.29%), Pfizer/BioNTech (0.12%) and Johnson & Johnson (0.09%).[73]

Between 21 December 2020 and 19 March 2021, CNCAV received five reports of death among people who received a COVID-19 vaccine.[75] However, the National Institute of Public Health (INSP) classified them as "coincidences", ruling out any direct link between vaccination and deaths.[76] Moreover, between 1 January and 14 March 2021, INSP recorded 89 deaths (a fatality rate of 0.002% of the people who completed the vaccination scheme)[77] among COVID-19-positive people who previously got vaccinated; 12 of them received both doses.[76]

Statistics[]

Total number of COVID-19 vaccinations administered[]

The following chart shows the total number of doses administered.[78]

Daily number of COVID-19 vaccinations administered by manufacturer[]

The following chart shows the daily number of doses administered, broken down by vaccine manufacturer.[73]

Percentage of vaccinated according to the vaccine received (as of 1 July 2021)[73]

  Pfizer/BioNTech (78.78%)
  Oxford/AstraZeneca (9.13%)
  Moderna (7.69%)
  Johnson & Johnson (6.39%)

COVID-19 vaccinations by county[]

As of 11 May 2021[79]
County Eligible population[a] Vaccinated population Percentage
Bucharest 1,544,269 621,877
40.27%
Cluj 601,200 214,809
35.73%
Sibiu 329,126 95,183
28.92%
Brașov 454,588 130,921
28.80%
Timiș 594,273 165,267
27.81%
Constanța 555,842 152,190
27.38%
Ilfov 399,350 99,079
24.81%
Alba 272,693 66,783
24.49%
Sălaj 172,239 39,305
22.82%
Satu Mare 271,884 61,555
22.64%
Mureș 438,723 98,932
22.55%
Iași 636,498 140,730
22.11%
Prahova 602,747 132,604
22.00%
Dolj 524,789 114,666
21.85%
Hunedoara 323,613 70,612
21.82%
Vâlcea 299,151 62,104
20.76%
Maramureș 380,972 79,052
20.75%
Bihor 463,590 95,639
20.63%
Tulcea 160,489 31,697
19.75%
Arad 348,425 68,605
19.69%
Bistrița-Năsăud 224,734 43,351
19.29%
Galați 417,369 78,465
18.80%
Harghita 247,989 46,052
18.57%
Ialomița 208,051 38,531
18.52%
Argeș 487,439 89,932
18.45%
Gorj 267,100 48,345
18.10%
Dâmbovița 410,419 74,163
18.07%
Călărași 231,187 39,625
17.14%
Buzău 344,659 58,799
17.06%
Olt 333,829 55,015
16.48%
Caraș-Severin 229,437 37,742
16.45%
Teleorman 281,959 44,944
15.94%
Vaslui 295,957 46,021
15.55%
Vrancea 261,499 40,532
15.50%
Brăila 243,286 37,490
15.41%
Covasna 164,550 25,094
15.25%
Mehedinți 204,156 30,909
15.14%
Neamț 361,439 52,228
14.45%
Bacău 473,020 66,743
14.11%
Giurgiu 221,820 29,968
13.51%
Botoșani 308,834 41,446
13.42%
Suceava 498,368 65,236
13.09%
  1. ^ Persons who have reached the age of 16

Efficacy[]

According to the National Center for Surveillance and Control of Communicable Diseases, between 27 December 2020 and 11 April 2021, 18,630 people (or 0.81% of all people vaccinated with the first dose) tested positive for SARS-CoV-2 after being administered the first dose of vaccine.[80] The median time from the first dose to the date of confirmation was 11 days.[80] During the same period, 2,983 people (or 0.21% of all people vaccinated with both doses) became infected with SARS-CoV-2 after the second dose; most were asymptomatic or mild cases.[80]

Opinion polls[]

Similar to neighboring countries, an important part of the Romanian population is reluctant to vaccination. The most commonly cited reasons are fear of adverse reactions and distrust of the vaccine's effectiveness.[81][82] In September 2020, before the launch of the first anti-COVID-19 vaccine, only 29% of Romanians in urban areas were determined to get vaccinated. The vaccination intention has increased significantly over the months, so that in February 2021, 51% of them intended to get vaccinated when they would have the opportunity to schedule for vaccination.[83] The vaccination intention is higher among men, people over 45, people with higher education and people with high incomes in urban areas.[82]

See also[]

  • Deployment of COVID-19 vaccines
  • COVID-19 pandemic in Romania
  • COVID-19 vaccination in Moldova

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