Dihydroorotase
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | CAD | ||||||
NCBI gene | 790 | ||||||
HGNC | 1424 | ||||||
OMIM | 114010 | ||||||
RefSeq | NM_004341 | ||||||
UniProt | P27708 | ||||||
Other data | |||||||
EC number | 3.5.2.3 | ||||||
Locus | Chr. 2 p22-p21 | ||||||
|
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarboymalase. Dihydroorotase is a zinc metalloenzyme.[3]
See also[]
- Pyrimidine biosynthesis
References[]
- ^ Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194.
- ^ Lieberman I, Kornberg A (April 1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal of Biological Chemistry. 207 (2): 911–24. PMID 13163076.
- ^ Voet, Donald (2011). Biochemistry. Judith G. Voet. Hoboken, NJ: John Wiley & Sons. ISBN 978-0-470-57095-1. OCLC 690489261.
External links[]
- Dihydroorotase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.5.2.3
Categories:
- Genes on human chromosome 2
- EC 3.5.2
- Transferase stubs