|
---|
α1 | Agonists |
- 6-FNE
- Amidephrine
- Buspirone
- Cirazoline
- Corbadrine
- Deoxyepinephrine (epinine, N-methyldopamine)
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Epinephrine
- Etilefrine
- Etilevodopa
- Ethylnorepinephrine
- Ibopamine
- Indanidine
- Isometheptene
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Melevodopa
- Metaraminol
- Methoxamine
- Methyldopa
- Midodrine
- Naphazoline
- Norepinephrine
- Octopamine
- Oxymetazoline
- Phenylephrine
- Phenylpropanolamine
- Synephrine
- Tetryzoline
- Tiamenidine
- Xylometazoline
|
---|
Antagonists |
- Abanoquil
- Ajmalicine
- Alfuzosin
- Anisodamine
- Anisodine
- Atiprosin
- Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone)
- Benoxathian
- Beta blockers (e.g., adimolol, amosulalol, arotinolol, carvedilol, eugenodilol, labetalol)
- Buflomedil
- Bunazosin
- Corynanthine
- Dapiprazole
- Domesticine
- Doxazosin
- Ergolines (e.g., acetergamine, ergotamine, dihydroergotamine, lisuride, nicergoline, terguride)
- Etoperidone
- Fenspiride
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- mCPP
- Mepiprazole
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Neldazosin
- Niaprazine
- Niguldipine
- Pardoprunox
- Pelanserin
- Perlapine
- Phendioxan
- Phenoxybenzamine
- Phentolamine
- Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
- Piperoxan
- Prazosin
- Quinazosin
- Quinidine
- Silodosin
- Spegatrine
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tiodazosin
- Tolazoline
- Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)
- Trimazosin
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Urapidil
- WB-4101
- Zolertine
|
---|
|
---|
α2 | Agonists |
- (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
- Apraclonidine
- Brimonidine
- Clonidine
- Corbadrine
- Deoxyepinephrine (epinine, N-methyldopamine)
- Detomidine
- Dexmedetomidine
- Dihydroergotamine
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Etilevodopa
- Ergotamine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Guanabenz
- Guanfacine
- Guanoxabenz
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Ibopamine
- Lofexidine
- Medetomidine
- Melevodopa
- Methyldopa
- Mivazerol
- Moxonidine
- Naphazoline
- Norepinephrine
- Oxymetazoline
- Phenylpropanolamine
- Piperoxan
- Rilmenidine
- Romifidine
- Talipexole
- Tetrahydrozoline
- Tiamenidine
- Tizanidine
- Tolonidine
- Urapidil
- Xylazine
- Xylometazoline
|
---|
Antagonists |
- 1-PP
- Adimolol
- Amesergide
- Aptazapine
- Atipamezole
- Atypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, zotepine)
- Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- Ketanserin
- Lisuride
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- Setiptiline
- Spegatrine
- Spiroxatrine
- Sunepitron
- Terguride
- Tolazoline
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
|
---|
|
---|
β | Agonists |
- Abediterol
- Alifedrine
- Amibegron
- Arbutamine
- Arformoterol
- Arotinolol
- BAAM
- Bambuterol
- Befunolol
- Bitolterol
- Broxaterol
- Buphenine
- Carbuterol
- Carmoterol
- Cimaterol
- Clenbuterol
- Colterol
- Corbadrine
- Denopamine
- Deoxyepinephrine (epinine, N-methyldopamine)
- Dipivefrine
- Dobutamine
- Dopamine
- Dopexamine
- Droxidopa (L-DOPS)
- Epinephrine
- Etafedrine
- Etilefrine
- Etilevodopa
- Ethylnorepinephrine
- Eugenodilol
- Fenoterol
- Formoterol
- Hexoprenaline
- Higenamine
- Ibopamine
- Indacaterol
- Isoetarine
- Isoprenaline
- Isoxsuprine
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Levosalbutamol
- Lubabegron
- Mabuterol
- Melevodopa
- Methoxyphenamine
- Methyldopa
- Mirabegron
- Norepinephrine
- Orciprenaline
- Oxyfedrine
- PF-610355
- Phenylpropanolamine
- Pirbuterol
- Prenalterol
- Ractopamine
- Procaterol
- Reproterol
- Rimiterol
- Ritodrine
- Salbutamol
- Salmeterol
- Solabegron
- Terbutaline
- Tretoquinol
- Tulobuterol
- Vibegron
- Vilanterol
- Xamoterol
- Zilpaterol
- Zinterol
|
---|
Antagonists | |
---|
|
---|
- See also: Receptor/signaling modulators
- Dopaminergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
|
|
---|
D1-like | Agonists |
- Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959
- Trepipam
- Ergolines: Cabergoline
- CY-208,243
- Dihydroergocryptine
- Lisuride
- Pergolide
- Terguride
- Dihydrexidine derivatives: A-77636
- A-86929
- Adrogolide (ABT-431, DAS-431)
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine
- Phenethylamines:
- Deoxyepinephrine (N-methyldopamine, epinine)
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- Melevodopa
- L-Phenylalanine
- L-Tyrosine
- Others: A-68930
- Apomorphine
- Nuciferine
- PF-6649751
- Propylnorapomorphine
- Rotigotine
- SKF-89,145
- Stepholidine
- Tavapadon
- Tetrahydropalmatine
|
---|
PAMs | |
---|
Antagonists |
- Typical antipsychotics: Butaclamol
- Chlorpromazine
- Chlorprothixene
- Flupentixol (flupenthixol) (+melitracen)
- Fluphenazine
- Loxapine
- Perphenazine (+amitriptyline)
- Thioridazine
- Thiothixene
- Trifluoperazine (+tranylcypromine)
- Zuclopenthixol
- Atypical antipsychotics: Asenapine
- Clorotepine
- Clotiapine
- Clozapine
- DHA-clozapine
- Fluperlapine
- Iloperidone
- Norclozapine
- Olanzapine (+fluoxetine)
- Paliperidone
- Quetiapine
- Risperidone
- Zicronapine
- Ziprasidone
- Zotepine
- Others:
- Ecopipam
- EEDQ
- Metitepine (methiothepin)
- Perlapine
- SCH-23390
|
---|
|
---|
D2-like | Agonists |
- Adamantanes: Amantadine
- Memantine
- Rimantadine
- Aminotetralins: 5-OH-DPAT
- 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232
- Ergolines: Bromocriptine
- Cabergoline
- Chanoclavine
- Dihydroergocryptine
- Epicriptine
- Ergocornine
- Lergotrile
- Lisuride
- LSD
- Pergolide
- Terguride
- Phenethylamines: Deoxyepinephrine (N-methyldopamine, epinine)
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Melevodopa
- Atypical antipsychotics: Alentemol (U-66444B)
- Aripiprazole (+sertraline)
- Aripiprazole lauroxil
- Bifeprunox
- Brexpiprazole
- Brilaroxazine
- Cariprazine
- F-15063
- Lumateperone
- Norclozapine
- Others: 3-PPP
- A-412997
- ABT-670
- ABT-724
- Adrafinil
- Aplindore
- Apomorphine
- Arketamine
- Armodafinil
- BP-897
- Captodiame
- CP-226,269
- Dizocilpine
- Esketamine
- Flibanserin
- Ketamine
- Mesulergine
- Modafinil
- OSU-6162
- Pardoprunox
- PD-128,907
- PD-168,077
- PF-219,061
- PF-592,379
- Phencyclidine
- Piribedil
- Pramipexole
- Preclamol
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Roxindole
- Salvinorin A
- SKF-83,959
- Sumanirole
- Talipexole
- Umespirone
- WAY-100,635
|
---|
Antagonists | |
---|
|
---|
- See also: Receptor/signaling modulators
- Adrenergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
|
|
---|
MT1 |
- Agonists: 2-Iodomelatonin
- 6-Hydroxymelatonin
- Agomelatine
- Fabomotizole (afobazole)
- GR-196,429
- Melatonin
- N-Acetylserotonin (normelatonin)
- Piromelatine
- Ramelteon
- Tasimelteon
- TIK-301 (LY-156,735)
|
---|
MT2 |
- Agonists: 2-Iodomelatonin
- 6-Hydroxymelatonin
- Agomelatine
- GR-196,429
- Melatonin
- N-Acetylserotonin (normelatonin)
- Piromelatine
- Ramelteon
- Tasimelteon
- TIK-301 (LY-156,735)
|
---|
Unsorted |
- Antagonists:
- (of MT3)
- Prazosin (of MT3)
|
---|
- See also: Receptor/signaling modulators
- Adrenergics
- Dopaminergics
- Serotonergics
- Monoamine metabolism modulators
|
|
---|
5-HT1 | 5-HT1A |
- Agonists: 8-OH-DPAT
- Adatanserin
- Amphetamine
- Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)
- Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)
- Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
- Bay R 1531
- Befiradol
- BMY-14802
- Cannabidiol
- Dimemebfe
- Dopamine
- Ebalzotan
- Eltoprazine
- Enciprazine
- Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
- F-15063
- F-15,599
- Flesinoxan
- Flibanserin
- Flumexadol
- Hypidone
- Lesopitron
- LY-293284
- mCPP
- MKC-242
- Naluzotan
- NBUMP
- Osemozotan
- Oxaflozane
- Pardoprunox
- Piclozotan
- Rauwolscine
- Repinotan
- Roxindole
- RU-24,969
- S-14,506
- S-14671
- S-15535
- Sarizotan
- Serotonin (5-HT)
- Sunepitron
- Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
- TGBA01AD
- U-92,016-A
- Urapidil
- Vilazodone
- Xaliproden
- Yohimbine
|
- Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
- Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)
- BMY-7,378
- CSP-2503
- Dotarizine
- Ergolines (e.g., metergoline)
- Flopropione
- Isamoltane
- Lecozotan
- Mefway
- Metitepine (methiothepin)
- MIN-117 (WF-516)
- MPPF
- NAN-190
- Robalzotan
- S-15535
- SB-649,915
- Spiperone
- Spiramide
- Spiroxatrine
- UH-301
- WAY-100135
- WAY-100635
- Xylamidine
|
- Unknown/unsorted: Acetryptine
- Carvedilol
- Ergolines (e.g., ergometrine (ergonovine))
|
|
---|
5-HT1B |
- Agonists: Anpirtoline
- CGS-12066A
- CP-93129
- CP-94253
- CP-122,288
- CP-135807
- Eltoprazine
- Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
- mCPP
- RU-24,969
- Serotonin (5-HT)
- Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
- TFMPP
- Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
- Vortioxetine
|
- Antagonists: AR-A000002
- Beta blockers (e.g., alprenolol, carteolol, isamoltane, oxprenolol, penbutolol, propranolol, tertatolol)
- Elzasonan
- Ergolines (e.g., metergoline)
- GR-127935
- Isamoltane
- LY-393558
- Metitepine (methiothepin)
- SB-216641
- SB-236057
- Yohimbine
|
- Unknown/unsorted: Ergolines (e.g., cabergoline, ergometrine (ergonovine), lisuride)
|
|
---|
5-HT1D |
- Agonists: CP-122,288
- CP-135807
- Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
- L-694247
- mCPP
- PNU-142633
- Serotonin (5-HT)
- TGBA01AD
- Triptans (e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan)
- Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)
| |
- Unknown/unsorted: Acetryptine
- Ergolines (e.g., lisuride, lysergol, pergolide)
|
|
---|
5-HT1E |
- Agonists: BRL-54443
- Ergolines (e.g., methysergide)
- Serotonin (5-HT)
- Triptans (e.g., eletriptan)
- Tryptamines (e.g., tryptamine)
|
- Antagonists: Metitepine (methiothepin)
|
- Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine), lysergol, methylergometrine (methylergonovine)
|
|
---|
5-HT1F |
- Agonists: BRL-54443
- CP-122,288
- Ergolines (e.g., bromocriptine, lysergol, methylergometrine (methylergonovine) methysergide)
- Lasmiditan
- LY-334370
- Serotonin (5-HT)
- Triptans (e.g., eletriptan, naratriptan, sumatriptan)
- Tryptamines (e.g., 5-MT)
|
- Antagonists: Metitepine (methiothepin)
- Mianserin
|
|
---|
|
---|
5-HT2 | 5-HT2A |
- Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
- 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
- 2C-B-FLY
- 2CB-Ind
- 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
- α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
- AL-34662
- AL-37350A
- Bromo-DragonFLY
- Dimemebfe
- DMBMPP
- DOx (e.g., DOB, DOC, DOI, DOM)
- Efavirenz
- Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
- Flumexadol
- IHCH-7113
- Jimscaline
- Lorcaserin
- MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
- O-4310
- Oxaflozane
- PHA-57378
- PNU-22394
- PNU-181731
- RH-34
- SCHEMBL5334361
- Phenethylamines (e.g., lophophine, mescaline)
- Piperazines (e.g., BZP, quipazine, TFMPP)
- Serotonin (5-HT)
- TCB-2
- TFMFly
- Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
- Antagonists: 5-I-R91150
- 5-MeO-NBpBrT
- AC-90179
- Adatanserin
- Altanserin
- Antihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)
- AMDA
- Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
- Chlorprothixene
- Cinanserin
- CSP-2503
- Deramciclane
- Dotarizine
- Eplivanserin
- Ergolines (e.g., amesergide, , LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- Fananserin
- Flibanserin
- Glemanserin
- Ketanserin
- KML-010
- LY-393558
- mCPP
- Medifoxamine
- Metitepine (methiothepin)
- MIN-117 (WF-516)
- Naftidrofuryl
- Nantenine
- Nelotanserin
- Opiranserin (VVZ-149)
- Pelanserin
- Phenoxybenzamine
- Pimavanserin
- Pirenperone
- Pizotifen
- Pruvanserin
- Rauwolscine
- Ritanserin
- Roluperidone
- S-14671
- Sarpogrelate
- Serotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)
- TGBA01AD
- Teniloxazine
- Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
- Tricyclic antidepressants (e.g., amitriptyline)
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)
- Volinanserin
- Xylamidine
- Yohimbine
|
- Unknown/unsorted: Ergolines (e.g., dihydroergotamine, nicergoline)
|
|
---|
5-HT2B |
- Agonists: 4-Methylaminorex
- Aminorex
- Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
- BW-723C86
- DOx (e.g., DOB, DOC, DOI, DOM)
- Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
- Lorcaserin
- MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
- Piperazines (e.g., TFMPP)
- PNU-22394
- Ro60-0175
- Serotonin (5-HT)
- Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
|
- Antagonists: Agomelatine
- Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, , N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)
- Cyproheptadine
- EGIS-7625
- Ergolines (e.g., amesergide, bromocriptine, lisuride, , LY-272015, mesulergine)
- Ketanserin
- LY-393558
- mCPP
- Metadoxine
- Metitepine (methiothepin)
- Pirenperone
- Pizotifen
- Propranolol
- PRX-08066
- Rauwolscine
- Ritanserin
- RS-127445
- Sarpogrelate
- SB-200646
- SB-204741
- SB-206553
- SB-215505
- SB-228357
- SDZ SER-082
- Tegaserod
- Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
- Trazodone
- Typical antipsychotics (e.g., chlorpromazine)
- TIK-301
- Yohimbine
|
- Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine))
|
|
---|
5-HT2C |
- Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
- 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
- α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
- A-372159
- AL-38022A
- Alstonine
- CP-809101
- Dimemebfe
- DOx (e.g., DOB, DOC, DOI, DOM)
- Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
- Flumexadol
- Lorcaserin
- MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
- MK-212
- ORG-12962
- ORG-37684
- Oxaflozane
- PHA-57378
- Phenethylamines (e.g., lophophine, mescaline)
- Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
- PNU-22394
- PNU-181731
- Ro60-0175
- Ro60-0213
- Serotonin (5-HT)
- Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
- Vabicaserin
- WAY-629
- WAY-161503
- YM-348
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- Antagonists: Adatanserin
- Agomelatine
- Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
- Captodiame
- CEPC
- Cinanserin
- Cyproheptadine
- Deramciclane
- Desmetramadol
- Dotarizine
- Eltoprazine
- Ergolines (e.g., amesergide, bromocriptine, , LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- Etoperidone
- Fluoxetine
- Ketanserin
- Ketotifen
- Latrepirdine (dimebolin)
- Medifoxamine
- Metitepine (methiothepin)
- Nefazodone
- Pirenperone
- Pizotifen
- Propranolol
- Ritanserin
- RS-102221
- S-14671
- SB-200646
- SB-206553
- SB-228357
- SB-242084
- SB-243213
- SDZ SER-082
- Tedatioxetine
- Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
- TIK-301
- Tramadol
- Trazodone
- Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
- Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
- Xylamidine
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- Unknown/unsorted: Efavirenz
- Ergolines (e.g., ergometrine (ergonovine), methylergometrine (methylergonovine))
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5-HT3–7 | 5-HT3 |
- Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)
- m-CPBG
- Phenylbiguanide
- Piperazines (e.g., BZP, mCPP, quipazine)
- RS-56812
- Serotonin (5-HT)
- SR-57227
- Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
- Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
- YM-31636
|
- Antagonists: Alosetron
- Anpirtoline
- AS-8112
- Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
- Azasetron
- Batanopride
- Bemesetron (MDL-72222)
- Bupropion
- Cilansetron
- CSP-2503
- Dazopride
- Dolasetron
- Galanolactone
- Granisetron
- Hydroxybupropion
- Lerisetron
- Memantine
- Ondansetron
- Palonosetron
- Ramosetron
- Renzapride
- Ricasetron
- Tedatioxetine
- Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
- Thujone
- Tropanserin
- Tropisetron
- Typical antipsychotics (e.g., loxapine)
- Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
- Vortioxetine
- Zacopride
- Zatosetron
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5-HT4 | |
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5-HT5A |
- Agonists: Ergolines (e.g., 2-Br-LSD (BOL-148), ergotamine, LSD)
- Serotonin (5-HT)
- Tryptamines (e.g., 5-CT)
- Valerenic acid
|
- Unknown/unsorted: Ergolines (e.g., metergoline, methysergide)
- Piperazines (e.g., naphthylpiperazine)
|
|
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5-HT6 |
- Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
- Hypidone
- Serotonin (5-HT)
- Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, , , ST-1936, tryptamine)
- WAY-181187
- WAY-208466
|
- Antagonists:
- Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
- AVN-101
- AVN-211
- Cerlapirdine
- EGIS-12,233
- Idalopirdine
- Ketanserin
- Latrepirdine (dimebolin)
- Metitepine (methiothepin)
- MS-245
- PRX-07034
- Ritanserin
- Ro 04-6790
- SB-258585
- SB-271046
- SB-357134
- SB-399885
- SB-742457
- Tetracyclic antidepressants (e.g., amoxapine, mianserin)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
- Typical antipsychotics (e.g., chlorpromazine, loxapine)
| |
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5-HT7 |
- Agonists: 8-OH-DPAT
- AS-19
- Bifeprunox
- E-55888
- Ergolines (e.g., LSD)
- LP-12
- LP-44
- LP-211
- RU-24,969
- Sarizotan
- Serotonin (5-HT)
- Triptans (e.g., frovatriptan)
- Tryptamines (e.g., 5-CT, 5-MT, bufotenin, N-Me-5-HT)
|
- Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
- Butaclamol
- DR-4485
- EGIS-12,233
- Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, , LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
- JNJ-18038683
- Ketanserin
- LY-215,840
- Metitepine (methiothepin)
- Ritanserin
- SB-258719
- SB-269970
- Spiperone
- Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
- Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
- Vortioxetine
|
- Unknown/unsorted: Ergolines (e.g., lisuride, pergolide)
- Piperazines (e.g., naphthylpiperazine)
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- See also: Receptor/signaling modulators
- Adrenergics
- Dopaminergics
- Melatonergics
- Monoamine reuptake inhibitors and releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
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