From Wikipedia, the free encyclopedia
This article
relies largely or entirely on a single source .
Relevant discussion may be found on the talk page . Please help by introducing citations to additional sources .Find sources: – · · · scholar · JSTOR (September 2018 )
EA-2054
Names
Preferred IUPAC name
N ,N ,N -Trimethyl-3-({[(propan-2-yl)oxy](methylphosphonoyl)}oxy)-5-{3-[3-(trimethylazaniumyl)phenoxy]propoxy}anilinium bis(tetraphenylboranuide)
Identifiers
3D model (JSmol )
show InChI=1S/C25H41N2O5P.2C24H20B/c1-20(2)31-33(9,28)32-25-18-22(27(6,7)8)17-24(19-25)30-15-11-14-29-23-13-10-12-21(16-23)26(3,4)5;2*1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24/h10,12-13,16-20H,11,14-15H2,1-9H3;2*1-20H/q+2;2*-1
Key: JVVQIPCTBBUOET-UHFFFAOYSA-N
show [B-](c1ccccc1)(c2ccccc2)(c3ccccc3)c4ccccc4.[B-](c1ccccc1)(c2ccccc2)(c3ccccc3)c4ccccc4.CC(C)OP(=O)(C)Oc5cc([N+](C)(C)C)cc(c5)OCCCOc6cccc(c6)[N+](C)(C)C
Properties
Chemical formula
C 73 H 81 B 2 N 2 O 5 P
Molar mass
119 .05−1
Appearance
Solid
Melting point
97–100 °C (207–212 °F; 370–373 K)
Insoluble
Solubility
Soluble in acetone
Hazards
Main hazards
Extremely toxic
Lethal dose or concentration (LD, LC):
LD50 (median dose )
74 μg/kg (Rats, IV)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
EA-2054 is an extremely toxic organophosphate nerve agent . It is an extremely potent acetylcholinesterase inhibitor that is resistant to atropine and oxime treatment.[1]
See also [ ] Nerve agent EA-2012 EA-2098 EA-2613 References [ ] show Agents used in chemical warfare incapacitation riot control Blood agents
Cyanogen [citation needed Cyanogen bromide Cyanogen chloride (CK)Hydrogen cyanide (AC)Arsine Hydrogen sulfide Phosphine Carbon monoxide Phosphorus trifluoride Methyl cyanoformate Blister agents
Arsenicals
Ethyldichloroarsine (ED)Methyldichloroarsine (MD)Phenyldichloroarsine (PD)Lewisite (L)Mustard gas (HD H HT HL HQ)Nitrogen mustard
Nerve agents
Neurotoxins
Saxitoxin (TZ)Botulinum toxin (BTX)Tetanospasmin (TeNT)Chlorophenylsilatrane Tetrodotoxin Aconitine Tetraethyllead Nettle agents Pulmonary/ Vomiting agents Incapacitating
Agent 15 (BZ)Dimethylheptylpyran (DMHP)EA-3167 EA-3443 EA-3580 EA-3834 Kolokol-1 LSD-25 PAVA spray Sleeping gas Lachrymatory
Xylyl bromide Pepper spray (OC)Mace (spray) CN CS CR CNS Benzyl chloride Benzyl bromide Benzyl iodide Bromobenzyl cyanide Thiophosgene Chloroacetone Bromoacetone Acrolein Phenacyl bromide Chloroacetophenone oxime Ethyl bromoacetate Ethyl iodoacetate Other
Methyl fluoroacetate Fluoroethyl fluoroacetate Ricin Abrin Enterotoxin type B Depleted uranium
White phosphorus
List of chemical warfare agents CB military symbol
show Neurotoxins
Bacterial
Botulinum toxin Tetanospasmin Cyanotoxins Plant toxins Mycotoxins Pesticides Nerve agents
Cyclosarin EA-3148 Novichok agent Sarin Soman Tabun VE VG VM VP VR VX GV EA-3990 EA-4056 T-1123 Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide) Fluorotabun Chinese VX EA-2192 Bicyclic phosphates Other
show Enzyme (modulators )
Transporter (modulators )
Release (modulators )
Inhibitors
SNAP-25 Botulinum toxin (A , , )VAMP Botulinum toxin (, , , ) Enhancers
LPHN α-Latrotoxin Others: Atracotoxins (e.g., robustoxin , )Crotoxin
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators
Categories :
Organophosphate nerve agents Acetylcholinesterase inhibitors Quaternary ammonium compounds Phenol ethers Phenol esters Phosphonate esters Isopropyl esters Tetraphenylborates Ester stubs Hidden categories:
Articles needing additional references from September 2018 All articles needing additional references Chemical articles without CAS registry number Chemicals without a PubChem CID Articles without InChI source Chemical pages without ChemSpiderID Articles without EBI source Articles without KEGG source Articles without UNII source Pages using collapsible list with both background and text-align in titlestyle Articles containing unverified chemical infoboxes Articles with short description Short description matches Wikidata All articles with unsourced statements Articles with unsourced statements from April 2020 All stub articles
