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EA-2054
Names
Preferred IUPAC name
N ,N ,N -Trimethyl-3-({[(propan-2-yl)oxy](methylphosphonoyl)}oxy)-5-{3-[3-(trimethylazaniumyl)phenoxy]propoxy}anilinium bis(tetraphenylboranuide)
Identifiers
3D model (JSmol )
show
InChI=1S/C25H41N2O5P.2C24H20B/c1-20(2)31-33(9,28)32-25-18-22(27(6,7)8)17-24(19-25)30-15-11-14-29-23-13-10-12-21(16-23)26(3,4)5;2*1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24/h10,12-13,16-20H,11,14-15H2,1-9H3;2*1-20H/q+2;2*-1
Key: JVVQIPCTBBUOET-UHFFFAOYSA-N
show
[B-](c1ccccc1)(c2ccccc2)(c3ccccc3)c4ccccc4.[B-](c1ccccc1)(c2ccccc2)(c3ccccc3)c4ccccc4.CC(C)OP(=O)(C)Oc5cc([N+](C)(C)C)cc(c5)OCCCOc6cccc(c6)[N+](C)(C)C
Properties
Chemical formula
C 73 H 81 B 2 N 2 O 5 P
Molar mass
1119 .05 g·mol−1
Appearance
Solid
Melting point
97–100 °C (207–212 °F; 370–373 K)
Insoluble
Solubility
Soluble in acetone
Hazards
Main hazards
Extremely toxic
Lethal dose or concentration (LD, LC):
LD50 (median dose )
74 μg/kg (Rats, IV) 15 μg/kg (Rabbits, IV)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
EA-2054 is an extremely toxic organophosphate nerve agent . It is an extremely potent acetylcholinesterase inhibitor that is resistant to atropine and oxime treatment.[1]
See also [ ]
Nerve agent
EA-2012
EA-2098
EA-2613
References [ ]
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Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)
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show Enzyme (modulators )
Transporter (modulators )
Release (modulators )
Inhibitors
SNAP-25 inactivators: Botulinum toxin (A , , )
VAMP inactivators: Botulinum toxin (, , , )
Enhancers
LPHN agonists: α-Latrotoxin
Others: Atracotoxins (e.g., robustoxin , )
Crotoxin
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators
Categories :
Organophosphate nerve agents Acetylcholinesterase inhibitors Quaternary ammonium compounds Phenol ethers Phenol esters Phosphonate esters Isopropyl esters Tetraphenylborates Ester stubs Hidden categories:
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