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Stercuronium iodide Other names MYC-1080; MYSC-1080
(3β)-N -Ethyl-N ,N -dimethylcona-4,6-dienin-3-aminium iodide
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 26 H 43 I N 2 Molar mass 510.548 g·mol−1 3D model (JSmol )
CC[N+](C)(C)[C@H]1CC[C@@]2([C@H]3CC[C@]45CN([C@H]([C@H]4CC[C@H]5[C@@H]3C=CC2=C1)C)C)C.[I-]
InChI=1S/C26H43N2.HI/c1-7-28(5,6)20-12-14-25(3)19(16-20)8-9-21-23(25)13-15-26-17-27(4)18(2)22(26)10-11-24(21)26;/h8-9,16,18,20-24H,7,10-15,17H2,1-6H3;1H/q+1;/p-1/t18-,20-,21+,22+,23-,24-,25-,26-;/m0./s1
Key:NZMZXOUHSHDAQQ-VIGAWJBNSA-M
Stercuronium iodide (INN , USAN ) (developmental code names MYC-1080 , MYSC-1080 ) is an aminosteroid neuromuscular blocking agent which was never marketed.[1] [2] It acts as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), and is also reported to be an acetylcholinesterase inhibitor .[1]
References [ ]
^ a b Kar A (2005). Medicinal Chemistry . New Age International. pp. 175–. ISBN 978-81-224-1565-0 .
^ Bowden RE, Collier B, Dripps RD, Duchen LW, Enderby GE, Ginsborg BL, Head S, Hobbiger F, Jenkinson DM, MacIntosh, Smith SE (13 March 2013). Neuromuscular Junction . Springer Science & Business Media. pp. 421–. ISBN 978-3-642-45476-9 .
Skeletal
muscle relaxants (
M03 )
Peripherally acting (primarily antinicotinic ,NMJ block )
Non-depolarizing
Curare alkaloids 4° ammonium agents
ultra-short duration: Gantacurium
long duration: Doxacurium
Dimethyltubocurarine
Pancuronium
Pipecuronium
Laudexium
Gallamine
Depolarizing
Choline derivatives : Suxamethonium (Succinylcholine)
ACh release inhibitors
Centrally acting
Carbamic acid estersBenzodiazepines
Bromazepam
Diazepam
Clonazepam
Flunitrazepam
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Nitrazepam
Temazepam
Tetrazepam
Nonbenzodiazepines Thienodiazepines Quinazolines Anticholinergics (Antimuscarinics )Other
Directly acting
Enzyme (modulators )
Transporter (modulators )
Release (modulators )
Inhibitors
SNAP-25 inactivators: Botulinum toxin (A , , )
VAMP inactivators: Botulinum toxin (, , , )
Enhancers
LPHN agonists: α-Latrotoxin
See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Nicotinic acetylcholine receptor modulators
nAChRs
Agonists (and PAMs )Antagonists (and NAMs )
Precursors (and prodrugs ) See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators
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