IRAK1

IRAK1
Identifiers
Aliases	IRAK1, IRAK, pelle, interleukin 1 receptor associated kinase 1
External IDs	OMIM: 300283 MGI: 107420 HomoloGene: 37496 GeneCards: IRAK1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,010,506 bp[1] End 154,019,902 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.61 cM Start 73,057,520 bp[2] End 73,067,524 bp[2]
RNA expression pattern Bgee Top expressed in parotid gland bone marrow tendon liver squamous epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding heat shock protein binding protein homodimerization activity kinase activity NF-kappaB-inducing kinase activity GO:0001948 protein binding protein heterodimerization activity ATP binding protein serine/threonine kinase activity Cellular component membrane lipid droplet plasma membrane endosome membrane interleukin-1 receptor complex nucleus cytoplasm cytosol Biological process cellular response to heat response to interleukin-1 positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway phosphorylation cytokine-mediated signaling pathway immune system process aging negative regulation of apoptotic process activation of NF-kappaB-inducing kinase activity MyD88-dependent toll-like receptor signaling pathway toll-like receptor signaling pathway positive regulation of transcription, DNA-templated protein phosphorylation JNK cascade response to lipopolysaccharide transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of NF-kappaB transcription factor activity protein complex oligomerization positive regulation of I-kappaB kinase/NF-kappaB signaling protein autophosphorylation toll-like receptor 9 signaling pathway cellular response to lipopolysaccharide negative regulation of NF-kappaB transcription factor activity nucleotide-binding oligomerization domain containing signaling pathway positive regulation of type I interferon production cellular response to hypoxia lipopolysaccharide-mediated signaling pathway signal transduction positive regulation of smooth muscle cell proliferation toll-like receptor 4 signaling pathway toll-like receptor 2 signaling pathway innate immune response type I interferon signaling pathway GO:0022415 viral process interleukin-1-mediated signaling pathway GO:0007243 intracellular signal transduction positive regulation of NIK/NF-kappaB signaling positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3654	16179
Ensembl	ENSG00000184216	ENSMUSG00000031392
UniProt	P51617	Q62406
RefSeq (mRNA)	NM_001025242 NM_001025243 NM_001569	NM_001177973 NM_001177974 NM_001177975 NM_001177976 NM_008363
RefSeq (protein)	NP_001020413 NP_001020414 NP_001560	NP_001171444 NP_001171445 NP_001171446 NP_001171447 NP_032389
Location (UCSC)	Chr X: 154.01 – 154.02 Mb	Chr X: 73.06 – 73.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.^[5][6]

Function[]

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

Interactions[]

IRAK1 has been shown to interact with:

Clinical significance[]

IRAK1 signaling is involved in rheumatoid arthritis.^[27][28]

References[]

Further reading[]