MAST2 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases MAST2 External IDs OMIM : 612257 MGI : 894676 HomoloGene : 7428 GeneCards : MAST2 Gene location (Human ) Chr. Chromosome 1 (human) [1] Band 1p34.1 Start 45,786,987 bp [1] End 46,036,122 bp [1]
Gene location (Mouse ) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 116,306,762 bp [2] End 116,464,183 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 45.79 – 46.04 Mb Chr 4: 116.31 – 116.46 Mb PubMed search[3] [4] Wikidata
Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene .[5] protein encoded by this gene controls TRAF6 and NF-kappaB activity.[6]
Interactions [ ] MAST2 has been shown to interact with PCLKC .[7]
Model organisms [ ] Model organisms have been used in the study of MAST2 function. A conditional knockout mouse line called Mast2tm1a(KOMP)Wtsi has been generated.[8] phenotypic screen [9] [10] [11] [12] [13] [14]
Mast2 knockout mouse phenotype
Characteristic
Phenotype
All data available at.[9] [14]
Insulin
Normal
Homozygous viability at P14
Normal
Homozygous Fertility
Normal
Body weight
Normal
Neurological assessment
Normal
Grip strength
Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Eye morphology
Normal
Clinical chemistry Normal
Haematology Normal
Peripheral blood leukocytes 16 Weeks
Normal
Heart weight
Normal
Salmonella Normal
Cytotoxic T Cell Function
Normal
Influenza Challenge
Normal
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000086015 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003810 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2" .^ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability" . J. Biol. Chem . 279 (42): 43675–83. doi :10.1074/jbc.M404328200 PMID 15308666 . ^ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation" . Carcinogenesis . 23 (7): 1139–48. doi :10.1093/carcin/23.7.1139 PMID 12117771 . ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ a b "International Mouse Phenotyping Consortium" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium" .
Further reading [ ]
Walden PD, Cowan NJ (1993). "A novel 205-kilodalton testis-specific serine/threonine protein kinase associated with microtubules of the spermatid manchette" . Mol. Cell. Biol . 13 (12): 7625–35. doi :10.1128/mcb.13.12.7625 . PMC 364834 PMID 8246979 . Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Walden PD, Millette CF (1996). "Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis" . Biol. Reprod . 55 (5): 1039–44. doi :10.1095/biolreprod55.5.1039 PMID 8902215 . Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 PMID 9872452 . Lumeng C, Phelps S, Crawford GE, Walden PD, Barald K, Chamberlain JS (1999). "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci . 2 (7): 611–7. doi :10.1038/10165 . PMID 10404183 . S2CID 20910888 . Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL (2000). "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding". Cancer Res . 60 (1): 35–7. PMID 10646847 . Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins" . J. Biol. Chem . 276 (12): 9206–13. doi :10.1074/jbc.M008745200 PMID 11099500 . Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation" . Carcinogenesis . 23 (7): 1139–48. doi :10.1093/carcin/23.7.1139 PMID 12117771 . Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs" . Genome Res . 12 (11): 1773–84. doi :10.1101/gr.406902 . PMC 187542 PMID 12421765 . Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics . 4 (2): 339–46. doi :10.1002/pmic.200300528 . PMID 14760703 . S2CID 8868600 . Zhou H, Xiong H, Li H, Plevy SE, Walden PD, Sassaroli M, Prestwich GD, Unkeless JC (2004). "Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation" . J. Immunol . 172 (4): 2559–68. doi :10.4049/jimmunol.172.4.2559 PMID 14764729 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability" . J. Biol. Chem . 279 (42): 43675–83. doi :10.1074/jbc.M404328200 PMID 15308666 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
Enzymes
Activity Regulation Classification
EC number Enzyme superfamily Enzyme family List of enzymes Kinetics Types
