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MAP3K9 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases MAP3K9 , MEKK9, MLK1, PRKE1, mitogen-activated protein kinase kinase kinase 9External IDs OMIM : 600136 MGI : 2449952 HomoloGene : 76377 GeneCards : MAP3K9 show Gene location (Human )Chr. Chromosome 14 (human) [1] Band 14q24.2 Start 70,722,526 bp [1] End 70,809,534 bp [1]
show Gene location (Mouse )Chr. Chromosome 12 (mouse)[2] Band 12|12 D1 Start 81,767,784 bp [2] End 81,827,949 bp [2]
show Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 14: 70.72 – 70.81 Mb Chr 12: 81.77 – 81.83 Mb PubMed search[3] [4] Wikidata
Mitogen-activated protein kinase kinase kinase 9 is an enzyme that in humans is encoded by the MAP3K9 gene .[5]
References [ ]
Further reading [ ]
Gallo KA, Mark MR, Scadden DT, et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity" . J. Biol. Chem . 269 (21): 15092–100. doi :10.1016/S0021-9258(17)36578-X . PMID 8195146 .
Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem . 213 (2): 701–10. doi :10.1111/j.1432-1033.1993.tb17810.x . PMID 8477742 .
Dorow DS, Devereux L, Tu GF, et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2" . Eur. J. Biochem . 234 (2): 492–500. doi :10.1111/j.1432-1033.1995.492_b.x . PMID 8536694 .
Xu Z, Maroney AC, Dobrzanski P, et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis" . Mol. Cell. Biol . 21 (14): 4713–24. doi :10.1128/MCB.21.14.4713-4724.2001 . PMC 87148 . PMID 11416147 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex" . J. Biol. Chem . 278 (48): 47922–7. doi :10.1074/jbc.M307357200 . PMID 14504284 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Durkin JT, Holskin BP, Kopec KK, et al. (2005). "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop". Biochemistry . 43 (51): 16348–55. doi :10.1021/bi049866y . PMID 15610029 .
External links [ ]
Overview of all the structural information available in the PDB for UniProt : P80192 (Mitogen-activated protein kinase kinase kinase 9) at the PDBe-KB .
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Genes on human chromosome 14 EC 2.7.11 Human chromosome 14 gene stubs