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STK38 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases STK38 , NDR, NDR1, serine/threonine kinase 38External IDs OMIM : 606964 MGI : 2442572 HomoloGene : 56033 GeneCards : STK38 Gene location (Human ) Chr. Chromosome 6 (human) [1] Band 6p21.31 Start 36,493,892 bp [1] End 36,547,479 bp [1]
Gene location (Mouse ) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 29,189,854 bp [2] End 29,226,969 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 6: 36.49 – 36.55 Mb Chr 17: 29.19 – 29.23 Mb PubMed search[3] [4] Wikidata
Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene .[5] [6]
References [ ]
Further reading [ ]
Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex" . Genome Res . 8 (6): 631–43. doi :10.1101/gr.8.6.631 . PMC 310739 . PMID 9647638 .
Millward TA, Heizmann CW, Schäfer BW, Hemmings BA (1998). "Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins" . EMBO J . 17 (20): 5913–22. doi :10.1093/emboj/17.20.5913 . PMC 1170919 . PMID 9774336 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Tamaskovic R, Bichsel SJ, Rogniaux H, et al. (2003). "Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase" . J. Biol. Chem . 278 (9): 6710–8. doi :10.1074/jbc.M210590200 . PMID 12493777 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 . PMID 14574404 .
Bhattacharya S, Large E, Heizmann CW, et al. (2004). "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase". Biochemistry . 42 (49): 14416–26. doi :10.1021/bi035089a . PMID 14661952 .
Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases" . J. Biol. Chem . 279 (23): 24444–51. doi :10.1074/jbc.M401999200 . PMID 15067004 .
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein" . J. Biol. Chem . 279 (34): 35228–35. doi :10.1074/jbc.M404542200 . PMID 15197186 .
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases" . Virology . 331 (1): 181–9. doi :10.1016/j.virol.2004.10.023 . PMID 15582665 .
Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation" . FEBS Lett . 579 (3): 683–9. doi :10.1016/j.febslet.2004.12.045 . PMID 15670829 . S2CID 33475235 .
Hergovich A, Bichsel SJ, Hemmings BA (2005). "Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation" . Mol. Cell. Biol . 25 (18): 8259–72. doi :10.1128/MCB.25.18.8259-8272.2005 . PMC 1234321 . PMID 16135814 .
Hergovich A, Lamla S, Nigg EA, Hemmings BA (2007). "Centrosome-associated NDR kinase regulates centrosome duplication" . Mol. Cell . 25 (4): 625–34. doi :10.1016/j.molcel.2007.01.020 . PMID 17317633 .
External links [ ]
PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein kinase 38
Enzymes
Activity Regulation Classification
EC number
Enzyme superfamily
Enzyme family
List of enzymes
Kinetics Types
Categories :
Genes on human chromosome 6 EC 2.7.11 Human chromosome 6 gene stubs