Second-generation antidepressant
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Second-generation antidepressant | |
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Drug class | |
Class identifiers | |
Use | Depressive disorders |
External links | |
MeSH | D018687 |
In Wikidata |
The second-generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction, approximately coinciding with the 1970s and 1980s, rather than by their chemical structure or by their pharmacological effect. As a consequence, there is some controversy over which treatments actually belong in this class.
The term "third generation antidepressant" is sometimes used to refer to newer antidepressants,[1] from the 1990s and 2000s, often selective serotonin reuptake inhibitors (SSRIs) such as; fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft), as well as some non-SSRI antidepressants such as mirtazapine, nefazodone, venlafaxine, duloxetine and reboxetine. However, this usage is not universal.
Examples[]
This list is not exhaustive, and different sources vary upon which items should be considered second-generation.
- Amineptine
- Amoxapine
- Bupropion
- Iprindole
- Maprotiline
- Medifoxamine
- Mianserin
- Nomifensine
- Tianeptine
- Trazodone
- Venlafaxine
- Viloxazine
See also[]
- Atypical antidepressant
- Development and discovery of SSRI drugs
- Pharmacology of antidepressants
- Tricyclic antidepressant
- Tetracyclic antidepressant
- Serotonin–norepinephrine reuptake inhibitor
- Serotonin antagonist and reuptake inhibitor
- Noradrenergic and specific serotonergic antidepressant
References[]
- ^ Olver JS, Burrows GD, Norman TR (2001). "Third-generation antidepressants: do they offer advantages over the SSRIs?". CNS Drugs. 15 (12): 941–54. doi:10.2165/00023210-200115120-00004. PMID 11735614. S2CID 39029287.
External links[]
- Second-Generation+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH)
- Diagrams at toxlab.co.uk
- Overview at sagepub.com
- Overview at psyweb.com
- Overview at sciencedaily.com
- Overview at sabryabdelfattah.tripod.com
- Antidepressants
- Nervous system drug stubs