11-cis-retinol dehydrogenase

11-cis-retinol dehydrogenase (EC 1.1.1.315, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD⁺ oxidoreductase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

11-cis-retinol---[retinal-binding-protein] + NAD⁺

\rightleftharpoons

11-cis-retinal---[retinol-binding-protein] + NADH + H⁺

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.

References[]

^ Simon A, Hellman U, Wernstedt C, Eriksson U (January 1995). "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". The Journal of Biological Chemistry. 270 (3): 1107–12. doi:10.1074/jbc.270.3.1107. PMID 7836368.
^ Wang J, Chai X, Eriksson U, Napoli JL (February 1999). "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". The Biochemical Journal. 338 ( Pt 1): 23–7. doi:10.1042/0264-6021:3380023. PMC 1220019. PMID 9931293.
^ Lidén M, Romert A, Tryggvason K, Persson B, Eriksson U (December 2001). "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". The Journal of Biological Chemistry. 276 (52): 49251–7. doi:10.1074/jbc.M107337200. PMID 11675386.
^ Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW (April 2003). "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". The Journal of Biological Chemistry. 278 (14): 12390–6. doi:10.1074/jbc.M212775200. PMID 12536149.

v t Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase Alcohol oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

v t Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)