6-phospho-beta-galactosidase

A 6-phospho-beta-galactosidase (EC 3.2.1.85) is an enzyme that catalyzes this chemical reaction:

a 6-phospho-beta-D-galactoside + H₂O ${\displaystyle \rightleftharpoons }$ 6-phospho-D-galactose + an alcohol

Thus, the two substrates of this enzyme are and H₂O, whereas its two products are and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 6-phospho-beta-D-galactoside 6-phosphogalactohydrolase. Other names in common use include phospho-beta-galactosidase, beta-D-phosphogalactoside galactohydrolase, phospho-beta-D-galactosidase, and 6-phospho-beta-D-galactosidase. This enzyme participates in galactose metabolism.

Structural studies[]

As of 2007, four structures have been solved for this class of enzymes, with PDB accession codes 1PBG, 2PBG, 3PBG, and 4PBG.

References[]

• Hengstenberg W, Penberthy WK, Morse ML (1970). "Purification of the staphylococcal 6-phospho-beta-D-- galactosidase". Eur. J. Biochem. 14 (1): 27–32. doi:10.1111/j.1432-1033.1970.tb00256.x. PMID 5447434.