All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific)
| All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.85 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
All-trans-nonaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) (EC 2.5.1.85, nonaprenyl diphosphate synthase, solanesyl diphosphate synthase, At-SPS2, At-SPS1, SPS1, SPS2) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction
- geranylgeranyl diphosphate + 5 isopentenyl diphosphate 5 diphosphate + all-trans-nonaprenyl diphosphate
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate.
n 2020, aclonifen was shown to inhibit the enzyme and is the first compound to have this mechanism of action as a herbicide.[4]
References[]
- ^ Hirooka K, Bamba T, Fukusaki E, Kobayashi A (March 2003). "Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase". The Biochemical Journal. 370 (Pt 2): 679–86. doi:10.1042/BJ20021311. PMC 1223189. PMID 12437513.
- ^ Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A (March 2005). "Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana". Bioscience, Biotechnology, and Biochemistry. 69 (3): 592–601. doi:10.1271/bbb.69.592. PMID 15784989.
- ^ Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M (December 2004). "Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana". Plant & Cell Physiology. 45 (12): 1882–8. doi:10.1093/pcp/pch211. PMID 15653808.
- ^ Kahlau, Sabine; Schröder, Florian; Freigang, Jörg; Laber, Bernd; Lange, Gudrun; Passon, Daniel; Kleeßen, Sabrina; Lohse, Marc; Schulz, Arno; von Koskull‐Döring, Pascal; Klie, Sebastian; Gille, Sascha (October 2020). "Aclonifen targets solanesyl diphosphate synthase, representing a novel mode of action for herbicides". Pest Management Science. 76 (10): 3377–3388. doi:10.1002/ps.5781.
External links[]
- All-trans-nonaprenyl+diphosphate+synthase+(geranylgeranyl-diphosphate+specific) at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- EC 2.5.1