From Wikipedia, the free encyclopedia
Cacotheline[1]
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Names
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Preferred IUPAC name
[(4bS,7aS,8aR,13S,13aR,13bS)-1-Nitro-2,3-dioxo-2,3,5,6,7a,8,8a,11,13,13a,13b,14-dodecahydro-7,9-methanooxepino[3,4-a]pyrrolo[2,3-d]carbazol-13-yl]acetic acid
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Other names
2,3-Dihydro-4-nitro-2,3-dioxo-9,10-secostrychnidin-10-oic acid
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Identifiers
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3D model (JSmol)
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ChemSpider
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ECHA InfoCard
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100.008.378
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UNII
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InChI=1/C21H21N3O7/c25-12-6-11-17(18(19(12)28)24(29)30)22-20-16-10-5-14-21(11,20)2-3-23(14)8-9(10)1-4-31-13(16)7-15(26)27/h1,6,10,13-14,16,20,22H,2-5,7-8H2,(H,26,27)/t10-,13-,14-,16-,20-,21+/m0/s1 Key: IVEMPCACOMNRGI-OFDJEBHLBG
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[O-][N+](=O)C=1C(=O)C(=O)/C=C3\C=1N[C@H]4[C@H]2[C@@H]6/C(=C\CO[C@H]2CC(=O)O)CN5CC[C@]34[C@@H]5C6
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Properties
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C21H21N3O7
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Molar mass
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427.41 g/mol
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Appearance
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Yellow crystals
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Density
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1.62 g/cm3
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Hazards
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Flash point
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374.6 °C (706.3 °F; 647.8 K)
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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Chemical compound
Cacotheline is an organic compound with the chemical formula C21H21N3O7. It is a nitro derivative of brucine obtained by reaction of brucine with nitric acid.[1] It is used as an indicator in the titrimetric analysis of tin ions (Sn2+).
References[]
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Receptor (ligands) | GlyR |
- Positive modulators: Alcohols (e.g., , chlorobutanol (chloretone), ethanol (alcohol), tert-butanol (2M2P), tribromoethanol, trichloroethanol, trifluoroethanol)
- Alkylbenzene sulfonate
- Anandamide
- Barbiturates (e.g., pentobarbital, sodium thiopental)
- Chlormethiazole
- Dihydropyridines (e.g., nicardipine)
- Etomidate
- Ginseng constituents (e.g., ginsenosides (e.g., ))
- Glutamic acid (glutamate)
- Ivermectin
- Ketamine
- Neuroactive steroids (e.g., alfaxolone, pregnenolone (eltanolone), pregnenolone acetate, minaxolone, ORG-20599)
- Nitrous oxide
- Penicillin G
- Propofol
- Tamoxifen
- Tetrahydrocannabinol
- Triclofos
- (e.g., atropine, bemesetron, cocaine, , tropisetron, zatosetron)
- Volatiles/gases (e.g., chloral hydrate, chloroform, desflurane, diethyl ether (ether), enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, toluene, trichloroethane (methyl chloroform), trichloroethylene)
- Xenon
- Zinc
- Negative modulators: Amiloride
- Benzodiazepines (e.g., bromazepam, clonazepam, diazepam, flunitrazepam, flurazepam)
- Daidzein
- Dihydropyridines (e.g., nicardipine, nifedipine, nitrendipine)
- Furosemide
- Genistein
- Ginkgo constituents (e.g., bilobalide, ginkgolides (e.g., , ginkgolide B, , , ))
- Imipramine
- NBQX
- Neuroactive steroids (e.g., , , deoxycorticosterone, DHEA sulfate, pregnenolone sulfate, progesterone)
- Opioids (e.g., codeine, dextromethorphan, dextrorphan, levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine)
- Picrotoxin (i.e., picrotin and picrotoxinin)
- Riluzole
- (e.g., bemesetron, , tropisetron, zatosetron)
- Verapamil
- Zinc
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NMDAR | |
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Transporter (blockers) | |
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- See also
- Receptor/signaling modulators
- GABA receptor modulators
- GABAA receptor positive modulators
- Ionotropic glutamate receptor modulators
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Categories:
- Nitro compounds
- Glycine receptor antagonists
- Nervous system drug stubs
Hidden categories:
- Articles without EBI source
- Articles without KEGG source
- Chembox CAS registry number linked
- ECHA InfoCard ID from Wikidata
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- Articles with short description
- Short description matches Wikidata
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