Minaxolone
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Other names | 11α-(Dimethylamino)-2β-ethoxy-3α-hydroxy-5α-pregnan-20-one |
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Formula | C25H43NO3 |
Molar mass | 405.623 g·mol−1 |
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Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed.[1][2][3] It is a positive allosteric modulator of the GABAA receptor,[4] as well as, less potently, a positive allosteric modulator of the glycine receptor.[4][5]
Chemistry[]
See also[]
- Alfadolone
- Alfaxolone
- Ganaxolone
- Hydroxydione
- Pregnanolone
- Renanolone
References[]
- ^ C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1358–. ISBN 978-0-412-46630-4.
- ^ J. G. Bovill; Michael B. Howie (1999). Clinical Pharmacology for Anaesthetists. W.B. Saunders. ISBN 978-0-7020-2167-1.
- ^ Hugh C. Hemmings; Philip M. Hopkins (2006). Foundations of Anesthesia: Basic Sciences for Clinical Practice. Elsevier Health Sciences. pp. 305–. ISBN 978-0-323-03707-5.
- ^ a b Giovanni Biggio; Robert H. Purdy (2001). Neurosteroids and Brain Function. Academic Press. pp. 196–. ISBN 978-0-12-366846-2.
- ^ Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ (May 2004). "The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors". Br J Anaesth. 92 (5): 704–11. CiteSeerX 10.1.1.519.3591. doi:10.1093/bja/aeh125. PMID 15033889.
Categories:
- Drugs not assigned an ATC code
- General anesthetics
- Neurosteroids
- Secondary alcohols
- Ethers
- Dimethylamino compounds
- Ketones
- GABAA receptor positive allosteric modulators
- Glycine receptor agonists
- Pregnanes
- Nervous system drug stubs