Suproclone ATC code
[6-(7-chloro-1,8-naphthyridin-2-yl)-5-oxo-3,7-dihydro-2H -[1,4]dithiino[2,3-c]pyrrol-7-yl] 4-propanoylpiperazine-1-carboxylate
CAS Number PubChem CID ChemSpider UNII KEGG ECHA InfoCard 100.071.330 Formula C 22 H 22 Cl N 5 O 4 S 2 Molar mass −1 3D model (JSmol )
O=C(N5CCN(C(=O)OC4C=1SCCSC=1C(=O)N4c2nc3nc(Cl)ccc3cc2)CC5)CC
InChI=1S/C22H22ClN5O4S2/c1-2-16(29)26-7-9-27(10-8-26)22(31)32-21-18-17(33-11-12-34-18)20(30)28(21)15-6-4-13-3-5-14(23)24-19(13)25-15/h3-6,21H,2,7-12H2,1H3
Y Key:IBAUKGNDWVSETP-UHFFFAOYSA-N
Y N Y (what is this?)
Suproclone is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs, developed by the French pharmaceutical company Rhône-Poulenc.[1] zopiclone , pagoclone and suriclone .
Suproclone is very similar in structure to the related drug suriclone , but little information has been published about it specifically. However it can be expected that the mechanism of action by which suproclone produces its sedative and anxiolytic effects is by modulating benzodiazepine receptors (resulting in an increased response to endogenous GABA ), in a similar manner to other drugs of this class.[2] [3]
References [ ]
^ Psychotropics.dk. "suproclone" . Retrieved 24 August 2009 . ^ Gardner CR (1988). "Pharmacological profiles in vivo of benzodiazepine receptor ligands". Drug Development Research . 12 (1): 1–28. doi :10.1002/ddr.430120102 . S2CID 85573551 . ^ Doble A, Martin I, Nutt D (23 October 2003). Calming the brain: benzodiazepines and related drugs from laboratory to clinic . Informa Healthcare. ISBN 1-84184-052-1
Hypnotics /sedatives (N05C )
GABAA
Alcohols Barbiturates Benzodiazepines
Brotizolam Cinolazepam Climazolam Clonazepam Doxefazepam Estazolam Flunitrazepam Flurazepam Flutoprazepam Lorazepam Loprazolam Lormetazepam Midazolam Nimetazepam Nitrazepam Phenazepam Quazepam Temazepam Triazolam Carbamates Imidazoles Monoureides Neuroactive steroids Nonbenzodiazepines Phenols Piperidinediones Quinazolinones Others
GABAB
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Antihistamines
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Serotonin antagonists and reuptake inhibitors
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Antipsychotics
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α2 -Adrenergic
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Antidepressants
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Amitriptyline Doxepin Trimipramine , etc.Tetracyclic antidepressants
Antipsychotics
Typical antipsychotics
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Cannabidiol
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GABA A receptor positive modulatorsAlcohols
Butanol Chloralodol Chlorobutanol (cloretone) Ethanol (alcohol) (alcoholic drink )Ethchlorvynol Isobutanol Isopropanol Menthol Methanol Methylpentynol Pentanol Petrichloral Propanol tert -Butanol (2M2P)tert -Pentanol (2M2B)Tribromoethanol Trichloroethanol Triclofos Trifluoroethanol Barbiturates Benzodiazepines Carbamates Flavonoids
Ampelopsin (dihydromyricetin) Apigenin Baicalein Baicalin Catechin EGC EGCG Hispidulin Luteolin Skullcap constituents (e.g., baicalin )Wogonin Imidazoles Kava constituents
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Fospropofol Propofol Thymol Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases
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3-Hydroxybutanal Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide )Carbamazepine Chloralose Chlormezanone Clomethiazole DEABL Dihydroergolines (e.g., dihydroergocryptine , , dihydroergotamine , ergoloid (dihydroergotoxine) )Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol (e.g., sulfonmethane (sulfonal) , tetronal , trional )
Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , )Unsorted benzodiazepine site positive modulators: α-Pinene See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
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