Haloxazolam Trade names Somelin (JP ) AHFS /Drugs.com International Drug Names Routes of administration Oral ATC code Legal status
CA : Schedule IV
DE : Anlage III (Special prescription form required)
US : Schedule IV
Metabolism Hepatic Excretion Renal
10-bromo-11b -(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d ][1,4]benzodiazepin-6-one
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEMBL Formula C 17 H 14 Br F N 2 O 2 Molar mass 377.213 g·mol−1 3D model (JSmol )
Fc1ccccc1C42OCCN2CC(=O)Nc3c4cc(Br)cc3
InChI=1S/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)
Y Key:XDKCGKQHVBOOHC-UHFFFAOYSA-N
Y
N Y (what is this?)
Haloxazolam (marketed in Japan under the brand name Somelin ), is a drug which is a benzodiazepine derivative.[1] [2] [3] It has similar hypnotic properties as the benzodiazepine drugs triazolam , temazepam , and flunitrazepam and as such is indicated for the treatment insomnia .[4] A study in cats comparing estazolam and haloxazolam found that haloxazolam only affects gamma motor neurons , whereas estazolam affects both alpha and gamma motor neurons.[5]
See also [ ]
References [ ]
^ Tanaka E, Terada M, Misawa S, Wakasugi C (June 1996). "Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel". Journal of Chromatography B: Biomedical Sciences and Applications . 682 (1): 173–8. doi :10.1016/0378-4347(96)00121-1 . PMID 8832439 .
^ "Benzodiazepine Names" . non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05 .
^ Guan F, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O (1999). "Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine" . Journal of Analytical Toxicology . 23 (1): 54–61. doi :10.1093/jat/23.1.54 . PMID 10022210 .
^ Tan X, Uchida S, Matsuura M, Nishihara K, Kojima T (February 2003). "Long-, intermediate- and short-acting benzodiazepine effects on human sleep EEG spectra" . Psychiatry and Clinical Neurosciences . 57 (1): 97–104. doi :10.1046/j.1440-1819.2003.01085.x . PMID 12519461 . S2CID 20863635 .
^ Sakai Y (October 1983). "Comparative study on the effects of haloxazolam and estazolam, new sleep inducing drugs, on the alpha- and gamma-motor systems" . Japanese Journal of Pharmacology . 33 (5): 1017–25. doi :10.1254/jjp.33.1017 . PMID 6139494 .
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See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators