Triclofos

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Triclofos
Triclofos-2D-skeletal.svg
Triclofos-3D-balls.png
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • 2,2,2-trichloroethanol dihydrogen phosphate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.624 Edit this at Wikidata
Chemical and physical data
FormulaC2H4Cl3O4P
Molar mass229.37 g·mol−1
3D model (JSmol)
SMILES
  • ClC(Cl)(Cl)COP(=O)(O)O
InChI
  • InChI=1S/C2H4Cl3O4P/c3-2(4,5)1-9-10(6,7)8/h1H2,(H2,6,7,8) checkY
  • Key:YYQRGCZGSFRBAM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  

Triclofos is a sedative drug used rarely for treating insomnia.[1]

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. The half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Triclofos is no longer available in the United States.[2]

Side effects[]

Side effects may include: headache, rash, dizziness, flatulence, confusion, nightmares, dependence, diarrhoea, constipation, nausea, vomiting, abdominal pain, and ataxia.

References[]

  1. ^ Erhorn S (2007). "Triclofos". xPharm: The Comprehensive Pharmacology Reference. Elsevier. pp. 1–4. doi:10.1016/B978-008055232-3.62797-7. ISBN 978-0-08-055232-3. Retrieved 29 February 2020.
  2. ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 February 2020.


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