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Fletazepam ATC code
7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1,4-benzodiazepine
CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard (EPA ) ECHA InfoCard 100.047.309 Formula C 17 H 13 Cl F 4 N 2 Molar mass 356.745 g·mol−1 3D model (JSmol )
FC1=CC=CC=C1C2=NCCN(CC(F)(F)F)C3=C2C=C(Cl)C=C3
InChI=1S/C17H13ClF4N2/c18-11-5-6-15-13(9-11)16(12-3-1-2-4-14(12)19)23-7-8-24(15)10-17(20,21)22/h1-6,9H,7-8,10H2
Y Key:CIZCSUNUBQXVFP-UHFFFAOYSA-N
Y
Fletazepam [1] is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is mainly notable for its strong muscle relaxant properties.[2]
Fletazepam is most closely related to other N -trifluoroethyl substituted benzodiazepines such as halazepam and quazepam .[3]
See also [ ]
References [ ]
^ DE 2106175 , Steinmann, Martin, "Neue 1-Polyfluoralkylbenzodiazepine und Verfahren zu ihrer Herstellung [Novel 1-polyfluoroalkylbenzodiazepines and processes for their preparation]", published 1971-09-30, assigned to Sherico Ltd.
^ Barnett A, Goldstein J, Fiedler EP, Taber RI (November 1974). "The pharmacology of fletazepam a centrally-acting muscle relaxant". Archives Internationales de Pharmacodynamie et de Therapie . 212 (1): 164–74. PMID 4476200 .
^ Iorio LC, Barnett A, Billard W (July 1984). "Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites". Life Sciences . 35 (1): 105–13. doi :10.1016/0024-3205(84)90157-7 . PMID 6738302 .
Benzodiazepines
1,4-Benzodiazepines 1,5-Benzodiazepines 2,3-Benzodiazepines* Triazolobenzodiazepines Imidazobenzodiazepines
Bretazenil
Climazolam
EVT-201
FG-8205
Flumazenil
GL-II-73
Imidazenil
123 I-Iomazenil
L-655,708
Loprazolam
Midazolam
PWZ-029
Remimazolam
Ro15-4513
Ro48-6791
Ro48-8684
Ro4938581
Sarmazenil
SH-053-R-CH3-2′F
Oxazolobenzodiazepines Thienodiazepines Thienotriazolodiazepines Thienobenzodiazepines *Pyridodiazepines Pyridotriazolodiazepines Pyrazolodiazepines Pyrrolodiazepines Tetrahydroisoquinobenzodiazepines Pyrrolobenzodiazepines *Benzodiazepine prodrugs * atypical activity profile (not GABAA receptor ligands)
GABA A receptor positive modulatorsAlcohols
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Org 25,435
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See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
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