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DS-1
4-chloro-N -(6,8-dibromo-2-thiophen-2-ylimidazo[1,2-a]pyridin-3-yl)benzamide
CAS Number PubChem CID IUPHAR/BPS ChemSpider CompTox Dashboard (EPA ) ECHA InfoCard 100.209.966 Formula C 18 H 10 Br 2 Cl N 3 O S Molar mass 511.62 g·mol−1 3D model (JSmol )
s4cccc4-c2nc1c(Br)cc(Br)cn1c2NC(=O)c(cc3)ccc3Cl
DS-1 is a drug from the imidazopyridine family, which is the first drug developed that acts as a GABAA receptor positive allosteric modulator (PAM) selective for the α4 β3 δ subtype, which is not targeted by other GABAA receptor PAMs such as the benzodiazepines or other nonbenzodiazepine drugs. Novel selective drugs such as DS-1 should prove useful in the study of this receptor subtype.[1]
See also [ ]
References [ ]
^ Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, et al. (January 2009). "Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus". Neuropharmacology . 56 (1): 182–9. doi :10.1016/j.neuropharm.2008.08.004 . PMID 18762200 . S2CID 207224202 .
GABA A receptor positive modulatorsAlcohols
Butanol
Chloralodol
Chlorobutanol (cloretone)
Ethanol (alcohol) (alcoholic drink )
Ethchlorvynol
Isobutanol
Isopropanol
Menthol
Methanol
Methylpentynol
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Petrichloral
Propanol
tert -Butanol (2M2P)
tert -Pentanol (2M2B)
Tribromoethanol
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Trifluoroethanol
Barbiturates Benzodiazepines Carbamates Flavonoids
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EGCG
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Monoureides Neuroactive steroids Nonbenzodiazepines Phenols
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Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases
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Org 25,435
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(e.g., sulfonmethane (sulfonal) , tetronal , trional )
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Unsorted benzodiazepine site positive modulators: α-Pinene
See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
Categories :
Benzamides Chloroarenes GABAA receptor positive allosteric modulators Imidazopyridines Organobromides Thiophenes Sedative stubs Hidden categories:
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