Drug used in treatment of joint and muscular pain
Niflumic acid AHFS /Drugs.com International Drug Names ATC code Elimination half-life 2.5 hr[1]
2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.022.289 Formula C 13 H 9 F 3 N 2 O 2 Molar mass 282.222 g·mol−1 3D model (JSmol ) Melting point 204 °C (399 °F)
C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
N Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N
N
N Y (what is this?)
Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2 . In experimental biology, it has been employed to inhibit chloride channels .[2] It has also been reported to act on GABA-A[3] and NMDA channels [4] and to block T-type calcium channels.[5]
References [ ]
^ "Half life" . Drug Bank . Retrieved 15 July 2011 .
^ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system" . The Journal of General Physiology . 83 (5): 703–25. doi :10.1085/jgp.83.5.703 . PMC 2215658 . PMID 6736917 .
^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology . 64 (3): 753–63. doi :10.1124/mol.64.3.753 . PMID 12920213 .
^ Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology . 41 (2): 217–22. PMID 1371581 .
^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (June 2012). "Niflumic acid blocks native and recombinant T-type channels" . Journal of Cellular Physiology . 227 (6): 2542–55. doi :10.1002/jcp.22992 . PMC 4146346 . PMID 21898399 .
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A , also N02BA )
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Key: underline indicates initially developed first-in-class compound of specific group; # WHO-Essential Medicines ; † withdrawn drugs ; ‡ veterinary use .
Topical products for joint and muscular pain (M02 )
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See also: Receptor/signaling modulators • Transient receptor potential channel modulators
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Precursors: Linoleic acid
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Prostaglandin G2
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See also
Receptor/signaling modulators
Leukotriene signaling modulators