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Glafenine |
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ATC code | |
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2,3-Dihydroxypropyl 2-[(7-chloro-4-quinolinyl)amino]benzoate
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CAS Number | |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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ChEBI | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.021.197 |
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Formula | C19H17ClN2O4 |
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Molar mass | 372.81 g·mol−1 |
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3D model (JSmol) | |
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Melting point | 169 to 170 °C (336 to 338 °F) |
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O=C(OCC(O)CO)c1ccccc1Nc2c3ccc(Cl)cc3ncc2
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InChI=1S/C19H17ClN2O4/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23/h1-9,13,23-24H,10-11H2,(H,21,22) Key:GWOFUCIGLDBNKM-UHFFFAOYSA-N
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Glafenine is a nonsteroidal anti-inflammatory drug (NSAID). Use of glafenine is limited due to the risk of anaphylaxis and acute kidney failure.[1][2]
See also[]
References[]
- ^ "Withdrawal of glafenine". The Lancet. 339 (8789): 357. 1992. doi:10.1016/0140-6736(92)91670-4. S2CID 54255503.
- ^ Kleinknecht D, Landais P, Goldfarb B (June 1986). "Analgesic and non-steroidal anti-inflammatory drug-associated acute renal failure: a prospective collaborative study". Clinical Nephrology. 25 (6): 275–81. PMID 2873910.
Analgesics (N02A, N02B) |
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Opioids | Opiates/opium |
- Codeine#
- Morphine# (+naltrexone)
- Opium
- Laudanum
- Paregoric
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Semisynthetic | |
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Synthetic | |
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Paracetamol-type | |
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NSAIDs | Propionates | |
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Oxicams | |
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Acetates | |
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COX-2 inhibitors | |
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Fenamates | |
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Salicylates | |
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Pyrazolones | |
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Others | |
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Cannabinoids |
- Cannabidiol
- Cannabis
- Nabilone
- Nabiximols
- Tetrahydrocannabinol (dronabinol)
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Ion channel modulators | Calcium blockers | |
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Sodium blockers |
- Carbamazepine
- Lacosamide
- Local anesthetics (e.g., cocaine, lidocaine)
- Mexiletine
- Nefopam
- Tricyclic antidepressants (e.g., amitriptyline#)
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Potassium openers | |
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Myorelaxants |
- Carisoprodol
- Chlorzoxazone
- Cyclobenzaprine
- Mephenoxalone
- Methocarbamol
- Orphenadrine
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Others | |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Receptor (ligands) | DP (D2) | DP1 |
- Agonists: Prostaglandin D2
- Treprostinil
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DP2 | |
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EP (E2) | EP1 | |
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EP2 |
- Agonists:
- Misoprostol
- Prostaglandin E1 (alprostadil)
- Prostaglandin E2 (dinoprostone)
- Treprostinil
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EP3 | |
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EP4 |
- Agonists: Lubiprostone
- Misoprostol
- Prostaglandin E1 (alprostadil)
- Prostaglandin E2 (dinoprostone)
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Unsorted | |
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FP (F2α) | |
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IP (I2) |
- Agonists:
- Beraprost
- Iloprost (ciloprost)
- Prostacyclin (prostaglandin I2, epoprostenol)
- Prostaglandin E1 (alprostadil)
- Selexipag
- Treprostinil
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TP (TXA2) |
- Agonists:
- Thromboxane A2
- U-46619
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Unsorted | |
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Enzyme (inhibitors) | COX (PTGS) | |
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PGD2S |
- Retinoids
- Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
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PGES | |
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PGFS | Bimatoprost |
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PGI2S | |
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TXAS | |
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Others | |
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- See also
- Receptor/signaling modulators
- Leukotriene signaling modulators
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Categories:
- Analgesics
- Vicinal diols
- Quinolines
- Anthranilates
- Nonsteroidal anti-inflammatory drugs
- Chloroarenes
- Analgesic stubs
Hidden categories:
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