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Proglumetacin Other names 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate AHFS /Drugs.com International Drug Names ATC code Metabolism Hepatic . Undergoes enterohepatic recirculation
3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H -indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N 2 -benzoyl-N,N -dipropyl-α-glutaminate
CAS Number PubChem CID ChemSpider UNII ChEBI CompTox Dashboard (EPA ) Formula C 46 H 58 Cl N 5 O 8 Molar mass 844.45 g·mol−1 3D model (JSmol )
Clc1ccc(cc1)C(=O)n3c2ccc(OC)cc2c(c3C)CC(=O)OCCN4CCN(CC4)CCCOC(=O)CCC(C(=O)N(CCC)CCC)NC(=O)c5ccccc5
InChI=1S/C46H58ClN5O8/c1-5-21-51(22-6-2)46(57)40(48-44(55)34-11-8-7-9-12-34)18-20-42(53)59-29-10-23-49-24-26-50(27-25-49)28-30-60-43(54)32-38-33(3)52(41-19-17-37(58-4)31-39(38)41)45(56)35-13-15-36(47)16-14-35/h7-9,11-17,19,31,40H,5-6,10,18,20-30,32H2,1-4H3,(H,48,55)
Y Key:PTXGHCGBYMQQIG-UHFFFAOYSA-N
Y
Proglumetacin (usually as the maleate salt, trade names Afloxan , Protaxon and Proxil ) is a nonsteroidal anti-inflammatory drug (NSAID). It is metabolized in the body to indometacin and proglumide ,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.
References [ ]
^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung . 37 (6): 698–702. PMID 3663267 .
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A , also N02BA )
pyrazolones /pyrazolidines salicylates acetic acid derivatives and related substancesoxicams propionic acid derivatives (profens)n -arylanthranilic acids (fenamates )COX-2 inhibitors (coxibs)other NSAID combinations Key:
underline indicates initially developed first-in-class compound of specific group;
# WHO-Essential Medicines ;
† withdrawn drugs ;
‡ veterinary use .
Receptor (ligands )
DP (D2 )
EP (E2 )
EP1 EP2
Agonists:
Misoprostol
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Treprostinil
EP3 EP4
Agonists: Lubiprostone
Misoprostol
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Unsorted
FP (F2α ) IP (I2 )
Agonists:
Beraprost
Iloprost (ciloprost)
Prostacyclin (prostaglandin I2 , epoprostenol)
Prostaglandin E1 (alprostadil)
Selexipag
Treprostinil
TP (TXA2 ) Unsorted
Enzyme (inhibitors )
Others
See also
Receptor/signaling modulators
Leukotriene signaling modulators
Categories :
Nonsteroidal anti-inflammatory drugs Prodrugs Indole ethers at the benzene ring Piperazines Carboxylate esters Benzamides Musculoskeletal system drug stubs Hidden categories:
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