GABA A receptor positive modulatorsAlcohols
Butanol
Chloralodol
Chlorobutanol (cloretone)
Ethanol (alcohol) (alcoholic drink )
Ethchlorvynol
Isobutanol
Isopropanol
Menthol
Methanol
Methylpentynol
Pentanol
Petrichloral
Propanol
tert -Butanol (2M2P)
tert -Pentanol (2M2B)
Tribromoethanol
Trichloroethanol
Triclofos
Trifluoroethanol
Barbiturates
Allobarbital
Alphenal
Amobarbital
Aprobarbital
Barbexaclone
Barbital
Benzobarbital
Benzylbutylbarbiturate
Brallobarbital
Brophebarbital
Butabarbital/Secbutabarbital
Butalbital
Buthalital
Butobarbital
Butallylonal
Carbubarb
Crotylbarbital
Cyclobarbital
Cyclopentobarbital
Difebarbamate
Enallylpropymal
Ethallobarbital
Eterobarb
Febarbamate
Heptabarb
Heptobarbital
Hexethal
Hexobarbital
Metharbital
Methitural
Methohexital
Methylphenobarbital
Narcobarbital
Nealbarbital
Pentobarbital
Phenallymal
Phenobarbital
Phetharbital
Primidone
Probarbital
Propallylonal
Propylbarbital
Proxibarbital
Reposal
Secobarbital
Sigmodal
Spirobarbital
Talbutal
Tetrabamate
Tetrabarbital
Thialbarbital
Thiamylal
Thiobarbital
Thiobutabarbital
Thiopental
Thiotetrabarbital
Valofane
Vinbarbital
Vinylbital
Benzodiazepines Carbamates
Carisbamate
Carisoprodol
Clocental
Cyclarbamate
Difebarbamate
Emylcamate
Ethinamate
Febarbamate
Felbamate
Hexapropymate
Hydroxyphenamate
Lorbamate
Mebutamate
Meprobamate
Nisobamate
Pentabamate
Phenprobamate
Procymate
Styramate
Tetrabamate
Tybamate
Flavonoids
Ampelopsin (dihydromyricetin)
Apigenin
Baicalein
Baicalin
Catechin
EGC
EGCG
Hispidulin
Luteolin
Skullcap constituents (e.g., baicalin )
Wogonin
Imidazoles
Etomidate
Metomidate
Propoxate
Kava constituents
Desmethoxyyangonin
Kavain
Methysticin
Yangonin
Monoureides
Acecarbromal
Apronal (apronalide)
Bromisoval
Carbromal
Neuroactive steroids
Acebrochol
Allopregnanolone (brexanolone)
Alfadolone
Alfaxalone
3α-Androstanediol
Androstenol
Androsterone
Certain anabolic-androgenic steroids
Cholesterol
DHDOC
3α-DHP
5α-DHP
5β-DHP
DHT
Etiocholanolone
Ganaxolone
Hydroxydione
Minaxolone
ORG-20599
ORG-21465
P1-185
Pregnanolone (eltanolone)
Progesterone
Renanolone
Testosterone
THDOC
Zuranolone
Nonbenzodiazepines
Cyclopyrrolones : Eszopiclone
Pagoclone
Pazinaclone
Suproclone
Suriclone
Zopiclone
Imidazopyridines : Alpidem
DS-1
Necopidem
Saripidem
Zolpidem
Pyrazolopyrimidines : Divaplon
Fasiplon
Indiplon
Lorediplon
Ocinaplon
Panadiplon
Taniplon
Zaleplon
Others : Adipiplon
CGS-8216
CGS-9896
CGS-13767
CGS-20625
CL-218,872
CP-615,003
ELB-139
GBLD-345
Imepitoin
JM-1232
L-838,417
Lirequinil (Ro41-3696)
NS-2664
NS-2710
NS-11394
Pipequaline
ROD-188
RWJ-51204
SB-205,384
SX-3228
TP-003
TPA-023
TP-13
U-89843A
U-90042
Viqualine
Y-23684
Phenols
Fospropofol
Propofol
Thymol
Piperidinediones
Glutethimide
Methyprylon
Piperidione
Pyrithyldione
Pyrazolopyridines
Cartazolate
Etazolate
ICI-190,622
Tracazolate
Quinazolinones
Afloqualone
Cloroqualone
Diproqualone
Etaqualone
Mebroqualone
Mecloqualone
Methaqualone
Methylmethaqualone
Nitromethaqualone
SL-164
Volatiles /gases
Acetone
Acetophenone
Acetylglycinamide chloral hydrate
Aliflurane
Benzene
Butane
Butylene
Centalun
Chloral
Chloral betaine
Chloral hydrate
Chloroform
Cryofluorane
Desflurane
Dichloralphenazone
Dichloromethane
Diethyl ether
Enflurane
Ethyl chloride
Ethylene
Fluroxene
Gasoline
Halopropane
Halothane
Isoflurane
Kerosine
Methoxyflurane
Methoxypropane
Nitric oxide
Nitrogen
Nitrous oxide
Norflurane
Paraldehyde
Propane
Propylene
Roflurane
Sevoflurane
Synthane
Teflurane
Toluene
Trichloroethane (methyl chloroform)
Trichloroethylene
Vinyl ether
Others/unsorted
3-Hydroxybutanal
Avermectins (e.g., ivermectin )
Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide )
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
DEABL
Dihydroergolines (e.g., dihydroergocryptine , , dihydroergotamine , ergoloid (dihydroergotoxine) )
Efavirenz
Etazepine
Etifoxine
Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )
Fluoxetine
Flupirtine
Hopantenic acid
Lanthanum
Lavender oil
Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )
Loreclezole
Menthyl isovalerate (validolum)
Monastrol
Niacin
Niacinamide
Org 25,435
Phenytoin
Propanidid
Retigabine (ezogabine)
Safranal
Seproxetine
Stiripentol
(e.g., sulfonmethane (sulfonal) , tetronal , trional )
Terpenoids (e.g., borneol )
Topiramate
Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , )
Unsorted benzodiazepine site positive modulators: α-Pinene
See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
Calcium
Potassium
Sodium
VGSCs
Blockers
Antiarrhythmics (class I): Ajmaline
Aprindine
Disopyramide
Dronedarone
Encainide
Flecainide
Lidocaine
Lorajmine
Lorcainide
Mexiletine
Moricizine
Pilsicainide
Prajmaline
Procainamide
Propafenone
Quinidine
Sparteine
Tocainide
Anticonvulsants:
Carbamazepine
Cenobamate
Chlorphenacemide
Eslicarbazepine acetate
Ethotoin
Fosphenytoin
Lacosamide
Licarbazepine
Mephenytoin
Oxcarbazepine
Oxitriptyline
Phenacemide
Pheneturide
Phenytoin
Rufinamide
Topiramate
Sodium valproate
Valnoctamide
Valproate pivoxil
Valproate semisodium
Valproic acid
Valpromide
Zonisamide
Analgesics:
DSP-2230
Funapide
PF-05089771
Ralfinamide
Raxatrigine
Toxins: Conotoxins
Neosaxitoxin
Saxitoxin
Tetrodotoxin
Zetekitoxin AB
Others: Buprenorphine
Evenamide
Menthol (mint )
Safinamide
Tricyclic antidepressants
Activators
ENaC
Blockers
Amiloride
Benzamil
Triamterene
Activators
ASICs
Blockers
Amiloride
Aspirin
Ibuprofen
Chloride
CaCCs
Blockers
Crofelemer
DIDS
Ethacrynic acid
Flufenamic acid
Fluoxetine
Furosemide
Glibenclamide
Mefloquine
Mibefradil
Niflumic acid
Activators
CFTR
Unsorted
Blockers
Bumetanide
Flufenamic acid
Meclofenamic acid
Mefenamic acid
Mepacrine
Niflumic acid
Tolfenamic acid
Trifluoperazine
Others
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
AMPAR
Antagonists:
Becampanel
Caroverine
CNQX
Dasolampanel
DNQX
Fanapanel (MPQX)
Kaitocephalin
Kynurenic acid
Kynurenine
Licostinel (ACEA-1021)
NBQX
Selurampanel
Tezampanel
Theanine
Topiramate
Zonampanel ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Cyclopropane
Enflurane
Ethanol (alcohol)
Evans blue
GYKI-52466
Halothane
Irampanel
Isoflurane
Perampanel
Pregnenolone sulfate
Sevoflurane
Talampanel ; Unknown/unsorted antagonists: Minocycline
KAR
Agonists: Main site agonists:
5-Iodowillardiine
AMPA
Domoic acid
Glutamate
Ibotenic acid
Kainic acid
Proline
Quisqualic acid
; Positive allosteric modulators: Cyclothiazide
Diazoxide
Enflurane
Halothane
Isoflurane
Antagonists:
CNQX
Dasolampanel
DNQX
Kaitocephalin
Kynurenic acid
Licostinel (ACEA-1021)
NBQX
NS102
Selurampanel
Tezampanel
Theanine
Topiramate
UBP-302 ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Enflurane
Ethanol (alcohol)
Evans blue
Pregnenolone sulfate
NMDAR
See also: Receptor/signaling modulators
Metabotropic glutamate receptor modulators
Glutamate metabolism/transport modulators
Receptor (ligands )
DP (D2 )
DP1
Agonists: Prostaglandin D2
Treprostinil
DP2
EP (E2 )
EP1
Agonists: Beraprost
Enprostil
Iloprost (ciloprost)
Latanoprost
Lubiprostone
Misoprostol
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Sulprostone
EP2
Agonists:
Misoprostol
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Treprostinil
EP3
Agonists: Beraprost
Enprostil
Iloprost (ciloprost)
Latanoprost
Misoprostol
Prostaglandin D2
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Ricinoleic acid
Sulprostone
EP4
Agonists: Lubiprostone
Misoprostol
Prostaglandin E1 (alprostadil)
Prostaglandin E2 (dinoprostone)
Unsorted
FP (F2α ) IP (I2 )
Agonists:
Beraprost
Iloprost (ciloprost)
Prostacyclin (prostaglandin I2 , epoprostenol)
Prostaglandin E1 (alprostadil)
Selexipag
Treprostinil
TP (TXA2 )
Agonists:
Thromboxane A2
U-46619
Antagonists: 12-HETE
Argatroban
Ifetroban
Picotamide
Ramatroban
Seratrodast
Terbogrel
Terutroban
Unsorted
Enzyme (inhibitors )
COX (PTGS )PGD2 S
Retinoids
Selenium (selenium tetrachloride , sodium selenite , selenium disulfide )
PGES
PGFS Bimatoprost
PGI2 S Tranylcypromine
TXAS
Others
Precursors: Linoleic acid
γ-Linolenic acid (gamolenic acid)
Dihomo-γ-linolenic acid
Diacylglycerol
Arachidonic acid
Prostaglandin G2
Prostaglandin H2
See also
Receptor/signaling modulators
Leukotriene signaling modulators
TRPA
Activators
4-Hydroxynonenal
4-Oxo-2-nonenal
4,5-EET
12S-HpETE
15-Deoxy-Δ12,14 -prostaglandin J2
α-Sanshool (ginger , Sichuan and melegueta peppers )
Acrolein
Allicin (garlic )
Allyl isothiocyanate (mustard , radish , horseradish , wasabi )
AM404
ASP-7663
Bradykinin
Cannabichromene (cannabis )
Cannabidiol (cannabis )
Cannabigerol (cannabis )
Cinnamaldehyde (cinnamon )
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (cumin )
Curcumin (turmeric )
(celery )
Diallyl disulfide
Dicentrine (Lindera spp.)
Formalin
Gingerols (ginger )
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
(celery , Angelica acutiloba )
Linalool (Sichuan pepper , thyme )
Methylglyoxal
Methyl salicylate (wintergreen )
N-Methylmaleimide
Nicotine (tobacco )
Oleocanthal (olive oil )
Paclitaxel (Pacific yew )
Paracetamol (acetaminophen)
PF-4840154
Phenacyl chloride
Polygodial (Dorrigo pepper )
Shogaols (ginger , Sichuan and melegueta peppers )
Tear gases
Tetrahydrocannabinol (cannabis )
Tetrahydrocannabiorcol
Thiopropanal S-oxide (onion )
Umbellulone (Umbellularia californica )
WIN 55,212-2
Blockers
TRPC
Activators
Adhyperforin (St John's wort )
Diacyl glycerol
GSK1702934A
Hyperforin (St John's wort )
Substance P
Blockers
DHEA-S
Flufenamic acid
GSK417651A
Meclofenamic acid
N-(p-Amylcinnamoyl)anthranilic acid
Niflumic acid
Pregnenolone sulfate
Progesterone
Tolfenamic acid
TRPM
Activators
ADP-ribose
Calcium (intracellular)
CIM-0216
Cold
Cooling Agent 10
Eucalyptol (eucalyptus )
Geraniol
Hydroxycitronellal
Icilin
Linalool
Menthol (mint )
Pregnenolone sulfate
(Ruta graveolens )
Steviol glycosides (e.g., stevioside ) (Stevia rebaudiana )
Sweet tastants (e.g., glucose , fructose , sucrose ; indirectly)
WS-12
Blockers
TRPML
TRPP
Activators
Triptolide (Tripterygium wilfordii )
Blockers
TRPV
Activators
2-APB
5',6'-EET
9-HODE
9-oxoODE
12S-HETE
12S-HpETE
13-HODE
13-oxoODE
20-HETE
α-Sanshool (ginger , Sichuan and melegueta peppers )
Allicin (garlic )
AM404
Anandamide
(Andrographis paniculata )
Camphor (camphor laurel , rosemary , camphorweed , African blue basil , camphor basil )
Cannabidiol (cannabis )
Cannabidivarin (cannabis )
Capsaicin (chili pepper )
Carvacrol (oregano , thyme , pepperwort , wild bergamot , others)
DHEA
Diacyl glycerol
Dihydrocapsaicin (chili pepper )
Estradiol
Eugenol (basil , clove )
Evodiamine (Euodia ruticarpa )
Gingerols (ginger )
GSK1016790A
Heat
Hepoxilin A3
Hepoxilin B3
Homocapsaicin (chili pepper )
Homodihydrocapsaicin (chili pepper )
Incensole (incense )
Lysophosphatidic acid
Low pH (acidic conditions)
Menthol (mint )
N-Arachidonoyl dopamine
N-Oleoylethanolamide
Nonivamide (PAVA) (PAVA spray )
Nordihydrocapsaicin (chili pepper )
Paclitaxel (Pacific yew )
Paracetamol (acetaminophen)
Phenylacetylrinvanil
Phorbol esters (e.g., )
Piperine (black pepper , long pepper )
Polygodial (Dorrigo pepper )
Probenecid
Protons
RhTx
(Ruta graveolens )
Resiniferatoxin (RTX) (Euphorbia resinifera /pooissonii )
Shogaols (ginger , Sichuan and melegueta peppers )
Tetrahydrocannabivarin (cannabis )
Thymol (thyme , oregano )
Tinyatoxin (Euphorbia resinifera /pooissonii )
Tramadol
Vanillin (vanilla )
Zucapsaicin
Blockers
α-Spinasterol (Vernonia tweediana )
AMG-517
AMG-9810
Cannabigerol (cannabis )
Cannabigerolic acid (cannabis )
(cannabis )
Cannabinol (cannabis )
Capsazepine
DHEA
DHEA-S
Flufenamic acid
GRC-6211
HC-067047
Lanthanum
Mavatrep
Meclofenamic acid
N-(p-Amylcinnamoyl)anthranilic acid
Niflumic acid
Pregnenolone sulfate
RN-9893
Ruthenium red
SB-366791
SB-705498
Tolfenamic acid
TRPV3-74a
See also: Receptor/signaling modulators • Ion channel modulators