Dexoxadrol ATC code Legal status
(2S)-2-[(4S)-2,2-di(phenyl)-1,3-dioxolan-4-yl]piperidine
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 20 H 23 N O 2 Molar mass 309.409 g·mol−1 3D model (JSmol )
O1C[C@@H](OC1(c2ccccc2)c3ccccc3)[C@H]4NCCCC4
InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m0/s1
Y Key:HGKAMARNFGKMLC-RBUKOAKNSA-N
Y
N Y (what is this?)
Dexoxadrol (Dioxadrol ) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. Dexoxadrol, along with another related drug etoxadrol , were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations .[1] [2]
References [ ]
^ Sax M, Wünsch B (2006). "Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity". Current Topics in Medicinal Chemistry . 6 (7): 723–32. doi :10.2174/156802606776894483 . PMID 16719812 .
^ Aepkers M, Wünsch B (December 2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol". Bioorganic & Medicinal Chemistry . 13 (24): 6836–49. doi :10.1016/j.bmc.2005.07.030 . PMID 16169732 .
Hallucinogens
Psychedelics (5-HT2A agonists)
Benzofurans
2C-B-FLY
2CBFly-NBOMe
5-MeO-BFE
5-MeO-DiBF
Bromo-DragonFLY
F-2
F-22
TFMFly
Lyserg‐ amides
1B-LSD
1cP-LSD
1P-ETH-LAD
1P-LSD
1V-LSD
2-Butyllysergamide
3-Pentyllysergamide
AL-LAD
ALD-52
BU-LAD
Diallyllysergamide
Dimethyllysergamide
ECPLA
Ergometrine
ETH-LAD
IP-LAD
LAE-32
LPD-824
LSA
LSD
LSD-Pip
LSH
LSM-775
LSZ
Methylergometrine
MIPLA
Methysergide
MLD-41
PARGY-LAD
PRO-LAD
Phenethyl‐ amines
Piperazines Tryptamines
alpha -alkyltryptamines
4,5-DHP-α-MT
5-MeO-α-ET
5-MeO-α-MT
α-ET
α-MT
x -DALT
(Daltacetin) 4-AcO-DALT
5-MeO-DALT
DALT
x -DET
(Ethacetin) 4-AcO-DET
(Ethocin) 4-HO-DET
5-MeO-DET
(T-9) DET
(Ethocybin) 4-PO-DET
x -DiPT
(Ipracetin) 4-AcO-DiPT
(Iprocin) 4-HO-DiPT
5-MeO-DiPT
DiPT
x -DMT
4,5-DHP-DMT
2,N,N-TMT
4-AcO-DMT
4-HO-5-MeO-DMT
4-Propionyloxy-DMT
5-AcO-DMT
5-Bromo-DMT
5-MeO-DMT
5-N ,N -TMT
7,N,N-TMT
α,N,N-TMT
(Bufotenin) 5-HO-DMT
DMT
Norbaeocystin
(Psilocin) 4-HO-DMT
(Psilocybin) 4-PO-DMT
x -DPT
(Deprocin) 4-HO-DPT
5-MeO-DPT
(The Light) DPT
Ibogaine-related
18-MAC
18-MC
Coronaridine
Ibogaine
Ibogamine
ME-18-MC
Noribogaine
Tabernanthine
Voacangine
x -MET
(Metocin) 4-HO-MET
(Metocetin) 4-AcO-MET
5-MeO-MET
MET
x -MiPT
(Mipracetin) 4-AcO-MiPT
(Miprocin) 4-HO-MiPT
5-Me-MiPT
(Moxy) 5-MeO-MiPT
MiPT
Others
4-HO-DBT
4-HO-EPT
4-HO-McPT
(Lucigenol) 4-HO-MPMI
(Meprocin) 4-HO-MPT
5-MeO-EiPT
5-MeO-MALT
5-MeO-MPMI
Aeruginascin
Baeocystin
DBT
EiPT
EPT
MPT
PiPT
Others
AL-38022A
ALPHA
Dimemebfe
Efavirenz
Glaucine
Lorcaserin
M-ALPHA
RH-34 Also empathogens in general (e. g.: 5-APB , 5-MAPB , 6-APB and other substituted benzofurans ).
Dissociatives (NMDAR antagonists )
Arylcyclo‐ hexylamines
Ketamine-related PCP-related Others
Diarylethylamines Morphinans
Dextrallorphan
Dextromethorphan
Dextrorphan
Racemethorphan
Racemorphan
Others
Deliriants (mAChR antagonists ) Others
Cannabinoids (CB1 agonists)
Natural
Salvinorin A
THC (Dronabinol)
THCV
Synthetic
D2 agonists
Apomorphine
Aporphine
Bromocriptine
Cabergoline
Lisuride
LSD
Memantine
Nuciferine
Pergolide
Phenethylamine
Piribedil
Pramipexole
Ropinirole
Rotigotine
Salvinorin A Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine , methylphenidate ), releasing agents (amphetamine , methamphetamine ), and precursors (levodopa ).
GABAA enhancers
CI-966
Eszopiclone
Ibotenic acid
Muscimol (Amanita muscaria )
Zaleplon
Zolpidem
Zopiclone
Inhalants (Mixed MOA )
Aliphatic hydrocarbons
Butane
Gasoline
Kerosene
Propane
Aromatic hydrocarbons
Ethers
Haloalkanes
Chlorofluorocarbons
Chloroform
κOR agonists
2-EMSB
Alazocine
Bremazocine
Butorphan
Butorphanol
Cyclazocine
Cyclorphan
Cyprenorphine
Diprenorphine
Enadoline
Herkinorin
Heroin
HZ-2
Ibogaine
Ketazocine
Levallorphan
Levomethorphan
Levorphanol
LPK-26
Metazocine
Morphine
Nalbuphine
Nalmefene
Nalorphine
Noribogaine
Oxilorphan
Pentazocine
Phenazocine
Proxorphan
Racemethorphan
Racemorphan
Salvinorin A
Spiradoline
Tifluadom
U-50488
U-69,593
Xorphanol
Oneirogens
Calea zacatechichi
Silene capensis
Galantamine
Others
Glaucine
Isoaminile
Noscapine
Pukateine