JWH-196 Legal status
UK : Class B
US : Schedule I
2-Methyl-3-(1-naphthalenylmethyl)-1-pentyl-1H -Indole
CAS Number ChemSpider UNII Formula C 25 H 27 N Molar mass 341.498 g·mol−1 3D model (JSmol )
CCCCCn1c(c(c2c1cccc2)Cc3cccc4c3cccc4)C
InChI=1S/C25H27N/c1-3-4-9-17-26-19(2)24(23-15-7-8-16-25(23)26)18-21-13-10-12-20-11-5-6-14-22(20)21/h5-8,10-16H,3-4,9,17-18H2,1-2H3
Key:LDTJKFUAZQDSQS-UHFFFAOYSA-N
JWH-196 is a synthetic cannabinoid receptor ligand from the naphthylmethylindole family. It is the indole 2-methyl derivative of related compound JWH-175 , and the carbonyl reduced analog of JWH-007 . The binding affinity of JWH-196 for the CB1 receptor is reported as Ki = 151 ± 18 nM.[1]
In the United States, all CB1 receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-196 are Schedule I Controlled Substances .[2]
See also [ ]
References [ ]
^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem . 11 (4): 539–549. doi :10.1016/s0968-0896(02)00451-0 . PMID 12538019 .
^ 21 U.S.C. § 812 : Schedules of controlled substances
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