4-Nonylphenylboronic acid ATC code
4-Nonylphenylboronic acid
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) Formula C 15 H 25 B O 2 Molar mass 248.17 g·mol−1 3D model (JSmol )
InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
Key:VONVJOGSLHAKOX-UHFFFAOYSA-N
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL , which it inhibits with an IC50 of 7900nM.[1] It is also a weaker inhibitor of the enzymes endothelial lipase and lipoprotein lipase , with IC50 values of 100 nM and 1400 nM respectively.[2]
See also [ ]
References [ ]
^ Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T (November 2008). "Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase". Journal of Medicinal Chemistry . 51 (22): 7057–60. doi :10.1021/jm801051t . PMID 18983140 .
^ O'Connell DP, LeBlanc DF, Cromley D, Billheimer J, Rader DJ, Bachovchin WW (February 2012). "Design and synthesis of boronic acid inhibitors of endothelial lipase". Bioorganic & Medicinal Chemistry Letters . 22 (3): 1397–401. doi :10.1016/j.bmcl.2011.12.043 . PMID 22225633 .
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