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JWH-116 Legal status
CA : Schedule II
DE : NpSG (Industrial and scientific use only)
UK : Class B
US : Schedule I
(2-Ethyl-1-pentyl-1H -indol-3-yl)-1-naphthalenylmethanone
CAS Number ChemSpider UNII CompTox Dashboard (EPA ) Formula C 26 H 27 N O Molar mass 369.508 g·mol−1 3D model (JSmol )
CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43
InChI=1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3
Key:AQHPTHKEKSWGPO-UHFFFAOYSA-N
JWH-116 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018 . The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM.[1]
In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 are Schedule I Controlled Substances .[2]
See also [ ]
References [ ]
^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, et al. (February 2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor". Bioorganic & Medicinal Chemistry . 11 (4): 539–49. doi :10.1016/s0968-0896(02)00451-0 . PMID 12538019 .
^ 21 U.S.C. § 812 : Schedules of controlled substances
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