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JWH-185 Legal status
UK : Class B
US : Schedule I
3-[(4-Methoxy-1-naphthalenyl)methyl]-1-pentyl-1H -indole
CAS Number ChemSpider UNII Formula C 25 H 27 N O Molar mass 357.497 g·mol−1 3D model (JSmol )
CCCCCn1cc(c2c1cccc2)Cc3ccc(c4c3cccc4)OC
InChI=1S/C25H27NO/c1-3-4-9-16-26-18-20(22-11-7-8-13-24(22)26)17-19-14-15-25(27-2)23-12-6-5-10-21(19)23/h5-8,10-15,18H,3-4,9,16-17H2,1-2H3
Key:OTYBPWBZUDBUQS-UHFFFAOYSA-N
JWH-185 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-081 . The binding affinity of JWH-185 for the CB1 receptor is reported as Ki = 17 ± 3 nM.[1]
In the United States, all CB1 receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-185 are Schedule I Controlled Substances .[2]
See also [ ]
References [ ]
^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem . 11 (4): 539–549. doi :10.1016/s0968-0896(02)00451-0 . PMID 12538019 .
^ 21 U.S.C. § 812 : Schedules of controlled substances
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