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NMP-7
(9-pentylcarbazol-3-yl)-piperidin-1-ylmethanone
CAS Number PubChem CID ChemSpider Formula C 23 H 28 N 2 O Molar mass 348.490 g·mol−1 3D model (JSmol )
c3cccc1c3n(CCCCC)c(cc2)c1cc2C(=O)N4CCCCC4
InChI=1S/C23H28N2O/c1-2-3-7-16-25-21-11-6-5-10-19(21)20-17-18(12-13-22(20)25)23(26)24-14-8-4-9-15-24/h5-6,10-13,17H,2-4,7-9,14-16H2,1H3
Key:NZEVKZAEMSMLMC-UHFFFAOYSA-N
NMP-7 is a drug which acts as both a non-selective agonist of the CB1 and CB2 cannabinoid receptors , and also as a blocker of T-type calcium channels , the target of anticonvulsant drugs such as ethosuximide . NMP-7 has an agonist EC50 of 96.9nM at CB1 and 10.5nM at CB2 , and an IC50 of 1.84μM for blocking Cav3.2 T-type calcium channels. In animal studies it produces potent analgesic effects in a variety of different tests.[1]
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