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LASSBio-881 PubChem CID ChemSpider ChEMBL Formula C 23 H 27 N 3 O 6 Molar mass 441.484 g·mol−1 3D model (JSmol )
Oc1c(C(C)(C)C)cc(cc1C(C)(C)C)\C=N\NC(=O)c2cc3OCOc3cc2[N](=O)=O
InChI=1S/C23H27N3O6/c1-22(2,3)15-7-13(8-16(20(15)27)23(4,5)6)11-24-25-21(28)14-9-18-19(32-12-31-18)10-17(14)26(29)30/h7-11,27H,12H2,1-6H3,(H,25,28)/b24-11+
Key:XEYZVZBNMMRXSN-BHGWPJFGSA-N
LASSBio-881 is a drug which acts as both a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors , and also as an antagonist of the TRPV1 receptor, as well as having antioxidant effects. It has potent anti-inflammatory and anti-hyperalgesic effects in animal studies.[1] [2]
has an identical structure sans the nitro FG .
References [ ]
^ Duarte CD, Tributino JL, Lacerda DI, Martins MV, Alexandre-Moreira MS, Dutra F, et al. (March 2007). "Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors". Bioorganic & Medicinal Chemistry . 15 (6): 2421–33. doi :10.1016/j.bmc.2007.01.013 . PMID 17275312 .
^ Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, et al. (April 2010). "LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation" . British Journal of Pharmacology . 159 (8): 1716–23. doi :10.1111/j.1476-5381.2010.00672.x . PMC 2925494 . PMID 20401963 .
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