JWH-030 Legal status
Naphthalen-1-yl-(1-pentylpyrrol-3-yl)methanone
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 20 H 21 N O Molar mass 291.394 g·mol−1 3D model (JSmol )
CCCCCn3cc(cc3)C(=O)c1cccc2ccccc12
InChI=1S/C20H21NO/c1-2-3-6-13-21-14-12-17(15-21)20(22)19-11-7-9-16-8-4-5-10-18(16)19/h4-5,7-12,14-15H,2-3,6,13H2,1H3
Key:VPBJQDBKZSHCPC-UHFFFAOYSA-N
JWH-030 is a research chemical which is a cannabinoid receptor agonist .[1] It has analgesic effects and is used in scientific research.[2] It is a partial agonist at CB1 receptors , with a Ki of 87 nM, making it roughly half the potency of THC .[3] It was discovered and named after John W. Huffman .
In the United States, CB1 receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-030 are Schedule I Controlled Substances .[4]
See also [ ]
References [ ]
^ Lainton JA, Huffman JW, Martin BR, Compton DR (February 1995). "1-Alkyl-3-(1-naphthoyl) pyrroles: A new class of cannabinoid". Tetrahedron Letters . 36 (9): 1401–4. doi :10.1016/0040-4039(95)00016-6 .
^ Pertwee RG, Griffin G, Lainton JA, Huffman JW (September 1995). "Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens". European Journal of Pharmacology . 284 (3): 241–7. doi :10.1016/0014-2999(95)00318-f . PMID 8666005 .
^ Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME (May 1998). "Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes". The Journal of Pharmacology and Experimental Therapeutics . 285 (2): 553–60. PMID 9580597 .
^ 21 U.S.C. § 812 : Schedules of controlled substances
Cannabinoids
Phytocannabinoids
Cannabichromenes Cannabicyclols Cannabidiols Cannabielsoins Cannabigerols Cannabinols and cannabinodiols Cannabitriols Delta-8-tetrahydrocannabinols Delta-9-tetrahydrocannabinols
Delta-9-THC (THC)
THCH
THCP
THCV
Miscellaneous cannabinoids Active metabolites
Endocannabinoids
Arachidonoyl ethanolamide (AEA; anandamide)
2-Arachidonoylglycerol (2-AG)
2-Arachidonyl glyceryl ether (2-AGE; noladin ether)
2-Oleoylglycerol (2-OG)
N-Arachidonoyl dopamine (NADA)
N-Arachidonylglycine (NAGly)
N-Arachidonoyl serotonin (AA-5-HT)
Docosatetraenoylethanolamide (DEA)
Lysophosphatidylinositol (LPI)
Oleamide
Oleoylethanolamide (OEA)
Palmitoylethanolamide (PEA)
RVD-Hpα
Stearoylethanolamide (SEA)
O-Arachidonoyl ethanolamine (O-AEA; virodhamine)
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Classical cannabinoids (dibenzopyrans) Non-classical cannabinoids Adamantoylindoles Benzimidazoles Benzoylindoles
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GW-405,833 (L-768,242)
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RCS-4
WIN 54,461
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A-796,260
A-834,735
FUB-144
UR-144
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PF-514273
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PSB-SB-487
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Rosonabant (E-6776)
SR-144,528
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TM-38837
VCHSR
See also: Cannabinoid receptor modulators (cannabinoids by pharmacology)
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