Triprolidine
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Chemical compound
Clinical data | |
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Trade names | Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin) |
AHFS/Drugs.com | Monograph |
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Routes of administration | Oral |
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Pharmacokinetic data | |
Bioavailability | 4% oral |
Protein binding | 90% |
Metabolism | Hepatic (CYP2D6) |
Elimination half-life | 4–6 hours |
Excretion | Renal |
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ECHA InfoCard | 100.006.934 |
Chemical and physical data | |
Formula | C19H22N2 |
Molar mass | 278.399 g·mol−1 |
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Melting point | 60 °C (140 °F) |
Solubility in water | 500 mg/mL (20 °C) |
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Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]
It was patented in 1948 and came into medical use in 1953.[3]
See also[]
- Benztropine
- Pseudoephedrine
References[]
- ^ a b Goldsmith P, Dowd PM (January 1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic Clinics. 11 (1): 87–95. doi:10.1016/S0733-8635(18)30285-7. PMID 8094649.
- ^ Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical Pharmacy. 3 (6): 638–43. PMID 6509877.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
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See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors |
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See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators |
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