Dimetindene Trade names Fenistil AHFS /Drugs.com International Drug Names Routes of Oral, topical ATC code Legal status
AU :S4 (Prescription only) UK :General sales list (GSL, OTC)
N ,N -Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H -inden-2-yl]ethan-1-amine
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.024.622 Formula C 20 H 24 N 2 Molar mass −1 3D model (JSmol ) Chirality Racemic mixture
n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3
Y Key:MVMQESMQSYOVGV-UHFFFAOYSA-N
Y
Dimetindene , also sold under the brand name Fenistil , is an antihistamine /anticholinergic . It is a first generation[1] H1 antagonist .[2] [3] blood-brain barrier .
Dimetindene is also an M2 receptor antagonist.[4]
It was patented in 1958 and came into medical use in 1960.[5]
Medical use [ ] Dimetindene is used orally and topically as an antipruritic .[6] hay fever .
It is commonly formulated as its maleic acid salt , dimethindene maleate.
Names [ ] It is sold under the brand name Fenistil among others.
References [ ]
^ Fromer LM, Ortiz GR, Dowdee AM (September 2008). "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey" . The World Allergy Organization Journal . 1 (9): 156–9. doi :10.1186/1939-4551-1-9-145 . PMC 3651039 PMID 23282579 . ^ "Dimetindene" . Drugs.com .^ "WikiGenes - Collaborative Publishing" . WikiGenes - Collaborative Publishing . Archived from the original on 2018-09-13. Retrieved 2019-03-13 .^ Matsumoto Y, Miyazato M, Furuta A, Torimoto K, Hirao Y, Chancellor MB, Yoshimura N (April 2010). "Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats" . Urology . 75 (4): 862–7. doi :10.1016/j.urology.2009.12.013 . PMC 2871158 PMID 20156651 . ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery ISBN 9783527607495 ^ Wexler L (June 1962). "A clinical evaluation of dimethindene". Current Therapeutic Research, Clinical and Experimental . 4 : 306–9. PMID 14006402 .
Antipruritics (D04 )
Antihistamines for topical useAnesthetics for topical useOthers
Antihistamines (R06 )
Benzimidazoles (* )
Astemizole Azelastine Bilastine Emedastine Mizolastine Talastine Diarylmethanes Ethylenediamines Tricyclics Others
Phenylpiperazines : Antidepressants (e.g., trazodone )Phenbenzamine For topical use
Bamipine Chloropyramine Chlorphenoxamine Clemastine Dimetindene Diphenhydramine Doxepin Isothipendyl Mepyramine (pyrilamine) Promethazine
H1
Agonists
2-Pyridylethylamine Betahistine Histamine HTMT L -HistidineUR-AK49 Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
Agonists
α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L -HistidineMethimepip Proxyfan Antagonists
H4
Agonists
4-Methylhistamine α-Methylhistamine Histamine L -HistidineOUP-16 VUF-8430 Antagonists
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors
mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate 4-DAMP Aclidinium bromide (+formoterol )Abediterol AF-DX 384 Ambutonium bromide Anisodamine Anisodine Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , dimetindene , diphenhydramine , doxylamine , meclizine , mequitazine , perlapine , phenindamine , pheniramine , phenyltoloxamine , promethazine , propiomazine , triprolidine )Atropine Atropine methonitrate Atypical antipsychotics (e.g., clozapine , fluperlapine , olanzapine (+fluoxetine ), , quetiapine , tenilapine , zotepine )Benactyzine Benzatropine (benztropine) Benzilone Benzilylcholine mustard Benzydamine Biperiden Bornaprine Camylofin CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,668 Caramiphen Cimetropium bromide Clidinium bromide Cloperastine CS-27349 Cyclobenzaprine Cyclopentolate Darifenacin Desfesoterodine Dexetimide Dicycloverine (dicyclomine) Dihexyverine Difemerine Diphemanil metilsulfate Ditran Drofenine EA-3167 EA-3443 EA-3580 EA-3834 Emepronium bromide Etanautine Etybenzatropine (ethybenztropine) Fenpiverinium Fentonium bromide Fesoterodine Flavoxate Glycopyrronium bromide (+beclometasone/formoterol , +indacaterol )Hexocyclium Himbacine Homatropine Imidafenacin Ipratropium bromide (+salbutamol )Isopropamide Hyoscyamine Mamba toxin 3 Mamba toxin 7 Mazaticol Mebeverine Meladrazine Mepenzolate Methantheline Methoctramine Methylatropine Methylhomatropine Methylscopolamine Metixene Muscarinic toxin 7 N-Ethyl-3-piperidyl benzilate N-Methyl-3-piperidyl benzilate Nefopam Octatropine methylbromide (anisotropine methylbromide) Orphenadrine Otenzepad (AF-DX 116) Otilonium bromide Oxapium iodide Oxitropium bromide Oxybutynin Oxyphencyclimine Oxyphenonium bromide PD-102,807 PD-0298029 Penthienate Pethidine Phenglutarimide Phenyltoloxamine Pipenzolate bromide Piperidolate Pirenzepine Piroheptine Pizotifen Poldine Pridinol Prifinium bromide Procyclidine Profenamine (ethopropazine) Propantheline bromide Propiverine Quinidine 3-Quinuclidinyl thiochromane-4-carboxylate Revefenacin Rociverine Scopolamine (hyoscine) Scopolamine butylbromide (hyoscine butylbromide) Sofpironium bromide Solifenacin SSRIs femoxetine , paroxetine )Telenzepine Terodiline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )Tiemonium iodide Timepidium bromide Tiotropium bromide Tofenacin Tolterodine Tricyclic antidepressants (e.g., amitriptyline (+perphenazine ), amitriptylinoxide , butriptyline , cidoxepin , clomipramine , desipramine , , dibenzepin , dosulepin (dothiepin) , doxepin , imipramine , lofepramine , nitroxazepine , northiaden (desmethyldosulepin) , nortriptyline , protriptyline , quinupramine , trimipramine )Tridihexethyl Trihexyphenidyl Trimebutine Tropatepine Tropicamide Trospium chloride Typical antipsychotics (e.g., chlorpromazine , chlorprothixene , cyamemazine (cyamepromazine) , loxapine , mesoridazine , thioridazine )Umeclidinium bromide (+vilanterol )WIN-2299 Xanomeline
Precursors (and prodrugs )
Acetyl-coA Adafenoxate Choline (lecithin )Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate (centrophenoxine) Phosphatidylcholine Phosphatidylethanolamine Phosphorylcholine Pirisudanol See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators
