Indacaterol/glycopyrronium bromide Indacaterol Ultra-long-acting beta-adrenoceptor agonist Glycopyrronium bromide Muscarinic anticholinergic Trade names Ultibro Breezhaler, Utibron Neohaler, Xoterna Breezhaler Pregnancy category Routes of administration Inhalation onlyATC code Legal status
AU : S4 (Prescription only)
UK : POM (Prescription only)
US : ℞-only
EU : Rx-only
CAS Number PubChem CID KEGG CompTox Dashboard (EPA )
Indacaterol/glycopyrronium bromide , sold under the brand name Ultibro Breezhaler among others, is a fixed-dose combination medication for inhalation consisting of the following two active ingredients:
Indacaterol maleate —an ultra-long-acting beta-adrenoceptor agonist (ultra-LABA);[1]
Glycopyrronium bromide (glycopyrrolate)—a muscarinic anticholinergic .
Indacaterol maleate/glycopyrronium bromide is used as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).[2]
The drug is marketed by Novartis under the trade names Ultibro Breezhaler and Utibron Neohaler in Europe and the United States, respectively.[2] [3] In 2016, Novartis licensed its U.S. commercial rights for Seebri Neohaler and Utibron Neohaler to Sunovion Pharmaceuticals.[4]
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Drugs for obstructive airway diseases : asthma /COPD (R03 )
Adrenergics , inhalants
Short-acting β2 agonists Long-acting β2 agonists Ultra-long-acting β2 agonists
Abediterol
Carmoterol
Indacaterol
Olodaterol
Vilanterol
Other
Glucocorticoids Anticholinergics /muscarinic antagonist Mast cell stabilizers Xanthines
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Ambuphylline
Aminophylline
Bamifylline
Choline theophyllinate
Doxofylline
Enprofylline
Etamiphylline
Proxyphylline
Theophylline
Eicosanoid inhibition
Leukotriene antagonists Arachidonate 5-lipoxygenase inhibitors Thromboxane receptor antagonists Non-xanthine PDE4 inhibitors
Others/unknown
Amlexanox
Eprozinol
Fenspiride ‡
Omalizumab
Combination products
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
α1
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β
See also: Receptor/signaling modulators
Dopaminergics
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Monoamine neurotoxins
mAChRs
Agonists Antagonists
3-Quinuclidinyl benzilate
4-DAMP
Aclidinium bromide (+formoterol )
Abediterol
AF-DX 384
Ambutonium bromide
Anisodamine
Anisodine
Antihistamines (first-generation) (e.g., brompheniramine , buclizine , captodiame , chlorphenamine (chlorpheniramine) , cinnarizine , clemastine , cyproheptadine , dimenhydrinate , dimetindene , diphenhydramine , doxylamine , meclizine , mequitazine , perlapine , phenindamine , pheniramine , phenyltoloxamine , promethazine , propiomazine , triprolidine )
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CAR-226,086
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CS-27349
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Dihexyverine
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EA-3167
EA-3443
EA-3580
EA-3834
Emepronium bromide
Etanautine
Etybenzatropine (ethybenztropine)
Fenpiverinium
Fentonium bromide
Fesoterodine
Flavoxate
Glycopyrronium bromide (+beclometasone/formoterol , +indacaterol )
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PD-102,807
PD-0298029
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Propantheline bromide
Propiverine
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3-Quinuclidinyl thiochromane-4-carboxylate
Revefenacin
Rociverine
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Scopolamine butylbromide (hyoscine butylbromide)
Sofpironium bromide
Solifenacin
SSRIs (e.g., femoxetine , paroxetine )
Telenzepine
Terodiline
Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )
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Timepidium bromide
Tiotropium bromide
Tofenacin
Tolterodine
Tricyclic antidepressants (e.g., amitriptyline (+perphenazine ), amitriptylinoxide , butriptyline , cidoxepin , clomipramine , desipramine , , dibenzepin , dosulepin (dothiepin) , doxepin , imipramine , lofepramine , nitroxazepine , northiaden (desmethyldosulepin) , nortriptyline , protriptyline , quinupramine , trimipramine )
Tridihexethyl
Trihexyphenidyl
Trimebutine
Tropatepine
Tropicamide
Trospium chloride
Typical antipsychotics (e.g., chlorpromazine , chlorprothixene , cyamemazine (cyamepromazine) , loxapine , mesoridazine , thioridazine )
Umeclidinium bromide (+vilanterol )
WIN-2299
Xanomeline
Precursors (and prodrugs )
Acetyl-coA
Adafenoxate
Choline (lecithin )
Citicoline
Cyprodenate
Dimethylethanolamine
Glycerophosphocholine
Meclofenoxate (centrophenoxine)
Phosphatidylcholine
Phosphatidylethanolamine
Phosphorylcholine
Pirisudanol
See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators