Corbadrine ATC code Legal status
In general: ℞ (Prescription only)
4-[(1R ,2S )-2-amino-1-hydroxypropyl]benzene-1,2-diol
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.113.606 Formula C 9 H 13 N O 3 Molar mass 183.207 g·mol−1 3D model (JSmol )
Oc1ccc(cc1O)[C@@H](O)[C@@H](N)C
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
Y Key:GEFQWZLICWMTKF-CDUCUWFYSA-N
Y
N Y (what is this?)
Corbadrine (INN ; marketed as Neo-Cobefrine ), also known as levonordefrin (USAN ) and α-methylnorepinephrine , is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States ,[1] [2] (usually in a pre-mixed solution with local anesthetics , such as mepivacaine ).[3]
Corbadrine is also a metabolite of the antihypertensive drug methyldopa ,[4] and plays a role in its pharmacology and effects.
See also [ ]
References [ ]
External links [ ]
Nordefrin at the US National Library of Medicine Medical Subject Headings (MeSH)
Decongestants and other nasal preparations (R01 )
Topical
Sympathomimetics , plain
Cyclopentamine
Ephedrine
Epinephrine
Fenoxazoline
Levomethamphetamine
Metizoline
Naphazoline
Oxymetazoline
Phenylephrine
Propylhexedrine
Tetryzoline
Tramazoline
Tuaminoheptane
Tymazoline
Xylometazoline
Antiallergic agents, excluding corticosteroids
mast cell stabilizer (some are also antihistamines) (Cromoglicic acid
Nedocromil
Azelastine
Olopatadine
Lodoxamide )
Corticosteroids
Beclometasone dipropionate
Betamethasone #
Budesonide
Ciclesonide
Dexamethasone
Flunisolide
Fluticasone (Fluticasone furoate , Fluticasone propionate )
Mometasone furoate
Prednisolone #
Tixocortol
Triamcinolone
Triamcinolone acetonide
Other nasal preparations
Cafaminol
Calcium hexamine thiocyanate
Eucalyptus oil
Framycetin
Hexamidine
Hyaluronan
Ipratropium bromide
Mupirocin
Retinol
Ritiometan
Saline water
Combination products
Systemic use:Sympathomimetics
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
Stimulants
Adamantanes
Adapromine
Amantadine
Bromantane
Memantine
Rimantadine
Adenosine antagonists Alkylamines
Cyclopentamine
Cypenamine
Cyprodenate
Heptaminol
Isometheptene
Levopropylhexedrine
Methylhexaneamine
Octodrine
Propylhexedrine
Tuaminoheptane
Ampakines Arylcyclohexylamines Benzazepines
6-Br-APB
SKF-77434
SKF-81297
SKF-82958
Cathinones Cholinergics Convulsants Eugeroics Oxazolines Phenethylamines Phenylmorpholines Piperazines
2C-B-BZP
3C-PEP
BZP
CM156
DBL-583
GBR-12783
GBR-12935
GBR-13069
GBR-13098
GBR-13119
MeOPP
MBZP
oMPP
Vanoxerine
Piperidines Pyrrolidines Racetams
Oxiracetam
Phenylpiracetam
Phenylpiracetam hydrazide
Tropanes Tryptamines Others ATC code : N06B
α1
Agonists
6-FNE
Amidephrine
Buspirone
Cirazoline
Corbadrine
Deoxyepinephrine (epinine, N -methyldopamine)
Dipivefrine
Dopamine
Droxidopa (L -DOPS)
Epinephrine
Etilefrine
Etilevodopa
Ethylnorepinephrine
Ibopamine
Indanidine
Isometheptene
L -DOPA (levodopa)
L -Phenylalanine
L -Tyrosine
Melevodopa
Metaraminol
Methoxamine
Methyldopa
Midodrine
Naphazoline
Norepinephrine
Octopamine
Oxymetazoline
Phenylephrine
Phenylpropanolamine
Synephrine
Tetryzoline
Tiamenidine
Xylometazoline
Antagonists
Abanoquil
Ajmalicine
Alfuzosin
Anisodamine
Anisodine
Atiprosin
Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )
Benoxathian
Beta blockers (e.g., adimolol , amosulalol , arotinolol , carvedilol , eugenodilol , labetalol )
Buflomedil
Bunazosin
Corynanthine
Dapiprazole
Domesticine
Doxazosin
Ergolines (e.g., acetergamine , ergotamine , dihydroergotamine , lisuride , nicergoline , terguride )
Etoperidone
Fenspiride
Hydroxyzine
Indoramin
Ketanserin
L-765,314
mCPP
Mepiprazole
Metazosin
Monatepil
Moxisylyte
Naftopidil
Nantenine
Neldazosin
Niaprazine
Niguldipine
Pardoprunox
Pelanserin
Perlapine
Phendioxan
Phenoxybenzamine
Phentolamine
Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )
Piperoxan
Prazosin
Quinazosin
Quinidine
Silodosin
Spegatrine
Spiperone
Talipexole
Tamsulosin
Terazosin
Tiodazosin
Tolazoline
Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )
Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )
Trimazosin
Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
Urapidil
WB-4101
Zolertine
α2
Agonists
(R)-3-Nitrobiphenyline
4-NEMD
6-FNE
Amitraz
Apraclonidine
Brimonidine
Clonidine
Corbadrine
Deoxyepinephrine (epinine, N -methyldopamine)
Detomidine
Dexmedetomidine
Dihydroergotamine
Dipivefrine
Dopamine
Droxidopa (L -DOPS)
Etilevodopa
Ergotamine
Epinephrine
Etilefrine
Ethylnorepinephrine
Guanabenz
Guanfacine
Guanoxabenz
L -DOPA (levodopa)
L -Phenylalanine
L -Tyrosine
Ibopamine
Lofexidine
Medetomidine
Melevodopa
Methyldopa
Mivazerol
Moxonidine
Naphazoline
Norepinephrine
Oxymetazoline
Phenylpropanolamine
Piperoxan
Rilmenidine
Romifidine
Talipexole
Tetrahydrozoline
Tiamenidine
Tizanidine
Tolonidine
Urapidil
Xylazine
Xylometazoline
Antagonists
1-PP
Adimolol
Amesergide
Aptazapine
Atipamezole
Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )
Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )
BRL-44408
Buflomedil
Cirazoline
Efaroxan
Esmirtazapine
Fenmetozole
Fluparoxan
Idazoxan
Ketanserin
Lisuride
mCPP
Mianserin
Mirtazapine
NAN-190
Pardoprunox
Phentolamine
Phenoxybenzamine
Piperoxan
Piribedil
Rauwolscine
Rotigotine
Setiptiline
Spegatrine
Spiroxatrine
Sunepitron
Terguride
Tolazoline
Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )
Yohimbine
β
Agonists
Abediterol
Alifedrine
Amibegron
Arbutamine
Arformoterol
Arotinolol
BAAM
Bambuterol
Befunolol
Bitolterol
Broxaterol
Buphenine
Carbuterol
Carmoterol
Cimaterol
Clenbuterol
Colterol
Corbadrine
Denopamine
Deoxyepinephrine (epinine, N -methyldopamine)
Dipivefrine
Dobutamine
Dopamine
Dopexamine
Droxidopa (L -DOPS)
Epinephrine
Etafedrine
Etilefrine
Etilevodopa
Ethylnorepinephrine
Eugenodilol
Fenoterol
Formoterol
Hexoprenaline
Higenamine
Ibopamine
Indacaterol
Isoetarine
Isoprenaline
Isoxsuprine
L -DOPA (levodopa)
L -Phenylalanine
L -Tyrosine
Levosalbutamol
Lubabegron
Mabuterol
Melevodopa
Methoxyphenamine
Methyldopa
Mirabegron
Norepinephrine
Orciprenaline
Oxyfedrine
PF-610355
Phenylpropanolamine
Pirbuterol
Prenalterol
Ractopamine
Procaterol
Reproterol
Rimiterol
Ritodrine
Salbutamol
Salmeterol
Solabegron
Terbutaline
Tretoquinol
Tulobuterol
Vibegron
Vilanterol
Xamoterol
Zilpaterol
Zinterol
Antagonists
See also: Receptor/signaling modulators
Dopaminergics
Serotonergics
Monoamine reuptake inhibitors
Monoamine releasing agents
Monoamine metabolism modulators
Monoamine neurotoxins