3',4'-Methylenedioxy-α-pyrrolidinopropiophenone Routes of administration By mouth , insufflation, Vaporization, IV, rectal, sublingualLegal status
DE : Anlage I (Authorized scientific use only)
UK : Class B
Metabolism Hepatic Excretion Primarily Urine (Renal) show
(RS )-1-(3,4-methylenedioxyphenyl)-2-(1-pyrrolidinyl)-1-propanone
CAS Number PubChem CID ChemSpider UNII Formula C 14 H 17 N O 3 Molar mass 247.294 g·mol−1 3D model (JSmol ) Chirality Racemic mixture show
c3c1OCOc1ccc3C(=O)C(C)N2CCCC2
show
InChI=1S/C14H17NO3/c1-10(15-6-2-3-7-15)14(16)11-4-5-12-13(8-11)18-9-17-12/h4-5,8,10H,2-3,6-7,9H2,1H3
Key:NIYQOTCYXGXMPI-UHFFFAOYSA-N
3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP ) is a stimulant designer drug . It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills.[1] It shares a similar chemical structure with α-PPP and MDPV ,[2] [3] [4] and has been shown to have reinforcing effects in rats.[5]
Metabolism [ ]
MDPPP appears to have a similar metabolic fate as MDPV .[4]
Legal Status [ ]
As of October 2015 MDPPP is a controlled substance in China.[6]
See also [ ]
References [ ]
^ Springer D, Fritschi G, Maurer HH (August 2003). "Metabolism and toxicological detection of the new designer drug 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone studied in urine using gas chromatography-mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences . 793 (2): 377–88. doi :10.1016/S1570-0232(03)00350-7 . PMID 12906913 .
^ Maurer HH, Kraemer T, Springer D, Staack RF (April 2004). "Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis". Therapeutic Drug Monitoring . 26 (2): 127–31. doi :10.1097/00007691-200404000-00007 . PMID 15228152 .
^ Staack RF, Maurer HH (June 2005). "Metabolism of designer drugs of abuse". Current Drug Metabolism . 6 (3): 259–74. doi :10.2174/1389200054021825 . PMID 15975043 .
^ Jump up to: a b Springer D, Staack RF, Paul LD, Kraemer T, Maurer HH (March 2005). "Identification of cytochrome P450 enzymes involved in the metabolism of 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes". Xenobiotica; the Fate of Foreign Compounds in Biological Systems . 35 (3): 227–37. doi :10.1080/00498250400028239 . PMID 16019948 .
^ Gannon BM, Galindo KI, Mesmin MP, Sulima A, Rice KC, Collins GT (May 2018). "Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats" . Neuropharmacology . 134 (Pt A): 28–35. doi :10.1016/j.neuropharm.2017.08.018 . PMC 5809320 . PMID 28811192 .
^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015 .
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