For other uses, see MPPP (disambiguation) .
Not to be confused with
desmethylprodine (opioid drug with acronym MPPP),
MPTP (neurotoxic impurity of desmethylprodine synthesis) or
MPP+ (neurotoxic metabolite of MPTP).
4'-Methyl-α-pyrrolidinopropiophenone Legal status
DE : Anlage I (Authorized scientific use only)
UK : Class B
US : Schedule I
Banned in Sweden [1]
(RS )-1-(4-methylphenyl)-2-(1-pyrrolidinyl)-1-propanone
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 14 H 19 N O Molar mass 217.312 g·mol−1 3D model (JSmol )
CC1=CC=C(C=C1)C(=O)C(C)N2CCCC2
InChI=1S/C14H19NO/c1-11-5-7-13(8-6-11)14(16)12(2)15-9-3-4-10-15/h5-8,12H,3-4,9-10H2,1-2H3
Key:APSJUNFBAXIXLK-UHFFFAOYSA-N
4'-Methyl-α-pyrrolidinopropiophenone (4-MePPP , MPPP or MαPPP ) is a stimulant drug and substituted cathinone . It is structurally very similar to α-PPP , with only one added methyl group in the para position on the phenyl ring. 4-MePPP was sold in Germany as a designer drug in the late 1990s and early 2000s,[2] [3] [4] along with a number of other pyrrolidinophenone derivatives .[5] [6] Although it has never achieved the same international popularity as its better-known relations α-PPP and MDPV , 4-MePPP is still sometimes found as an ingredient of grey-market "bath salt " blends[7] such as "NRG-3".[7]
See also [ ]
References [ ]
^ "Cannabinoider föreslås bli klassade som hälsofarlig vara" . Retrieved 29 June 2015 .
^ Springer, D; Peters, FT; Fritschi, G; Maurer, HH (2002). "Studies on the metabolism and toxicological detection of the new designer drug 4'-methyl-alpha-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometry". Journal of Chromatography B . 773 (1): 25–33. doi :10.1016/S1570-0232(01)00578-5 . PMID 12015267 .
^ Springer, D; Paul, LD; Staack, RF; Kraemer, T; Maurer, HH (2003). "Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes". Drug Metabolism and Disposition . 31 (8): 979–82. doi :10.1124/dmd.31.8.979 . PMID 12867484 .
^ Springer, D; Fritschi, G; Maurer, HH (2003). "Metabolism of the new designer drug alpha-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4'-methyl-alpha-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometry". Journal of Chromatography B . 796 (2): 253–66. doi :10.1016/j.jchromb.2003.07.008 . PMID 14581066 .
^ Maurer, HH; Kraemer, T; Springer, D; Staack, RF (2004). "Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis". Therapeutic Drug Monitoring . 26 (2): 127–31. doi :10.1097/00007691-200404000-00007 . PMID 15228152 . S2CID 9255084 .
^ Staack, RF; Maurer, HH (2005). "Metabolism of designer drugs of abuse". Current Drug Metabolism . 6 (3): 259–74. doi :10.2174/1389200054021825 . PMID 15975043 .
^ a b Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J (December 2010). "Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones". Drug Testing and Analysis . 3 (9): 569–75. doi :10.1002/dta.204 . PMID 21960541 .
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See also: Receptor/signaling modulators
Adrenergics
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