Lenperone

Lenperone
Clinical data
Trade names	Elanone-V
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 4-[4-(4-Fluorobenzoyl)piperidin-1-yl]-1-(4-fluorophenyl)butan-1-one;
CAS Number	24678-13-5; HCl: 24677-86-9;
PubChem CID	32593;
ChemSpider	30207;
UNII	13P4GX22ES; HCl: 96Q0TL6O3G ;
KEGG	D02668;
CompTox Dashboard (EPA)	DTXSID7046120 ;
ECHA InfoCard	100.042.166
Chemical and physical data
Formula	C22H23F2NO2
Molar mass	371.428 g·mol−1

Lenperone (Elanone-V) is a typical antipsychotic of the butyrophenone chemical class.^[1] It was first reported as an emetic in 1974,^[2] and its use in treatment of acute schizophrenia was reported in 1975.^[1] Related early antipsychotic agents include and .

Lenperone was never approved by the FDA for use in humans in the United States,^[3] but prior to 1989 it was approved for use in veterinary medicine for sedation.^[4]^[5]^[6]

References[]

^ ^a ^b Harris M (1975). "Treatment of Acute Schizophrenia with a New Butyrophenone-Lenperone". Journal of Clinical Pharmacology. 15 (2–3): 187–90. doi:10.1002/j.1552-4604.1975.tb02355.x. PMID 1091666. S2CID 28602974.
^ FR 2227868, Ward, John Wesley & Leonard, Charles A., "Antiemetic compositions containing piperidine derivatives", published 1974-11-29
^ Table 1. Marketed butyrophenones with approval status and indication in Miller AC, Khan AM, Castro Bigalli AA, Sewell KA, King AR, Ghadermarzi S, et al. (2019). "Neuroleptanalgesia for acute abdominal pain: a systematic review". Journal of Pain Research. 12: 787–801. doi:10.2147/JPR.S187798. PMC 6396833. PMID 30881092.
^ Booth NJ (1982). "Psychotropic Agents". In Booth NH, McDonald LE (ed.). Veterinary Pharmacology and Therapeutics (5th ed.). Ames, Iowa: Iowa State University Press. pp. 321–345.
^ Johnson SE, Zelner A, Sherding RG (April 1989). "Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs". Canadian Journal of Veterinary Research. 53 (2): 248–50. PMC 1255555. PMID 2565757.
^ FDA Veterinarian. U.S. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Veterinary Medicine. 1988. The firm requested withdrawal of approval because the products are no longer being marketed. Effective date: July 13, 1989

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[Harris-1] Harris M (1975). "Treatment of Acute Schizophrenia with a New Butyrophenone-Lenperone". Journal of Clinical Pharmacology. 15 (2–3): 187–90. doi:10.1002/j.1552-4604.1975.tb02355.x. PMID 1091666. S2CID 28602974.

[2] FR 2227868, Ward, John Wesley & Leonard, Charles A., "Antiemetic compositions containing piperidine derivatives", published 1974-11-29

[3] Table 1. Marketed butyrophenones with approval status and indication in Miller AC, Khan AM, Castro Bigalli AA, Sewell KA, King AR, Ghadermarzi S, et al. (2019). "Neuroleptanalgesia for acute abdominal pain: a systematic review". Journal of Pain Research. 12: 787–801. doi:10.2147/JPR.S187798. PMC 6396833. PMID 30881092.

[4] Booth NJ (1982). "Psychotropic Agents". In Booth NH, McDonald LE (ed.). Veterinary Pharmacology and Therapeutics (5th ed.). Ames, Iowa: Iowa State University Press. pp. 321–345.

[5] Johnson SE, Zelner A, Sherding RG (April 1989). "Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs". Canadian Journal of Veterinary Research. 53 (2): 248–50. PMC 1255555. PMID 2565757.

[6] FDA Veterinarian. U.S. Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Veterinary Medicine. 1988. The firm requested withdrawal of approval because the products are no longer being marketed. Effective date: July 13, 1989

[1]

[2]

[3]

[4]

[5]

[6]

v t Antipsychotics (N05A)
Typical	Butyrophenones: Benperidol Bromperidol Bromperidol decanoate Droperidol Haloperidol^# Haloperidol decanoate Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines: Fluspirilene Penfluridol Pimozide Phenothiazines: Acepromazine Acetophenazine Butaperazine Carphenazine (carfenazine)^‡ Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Fluphenazine decanoate Fluphenazine enanthate Levomepromazine (methotrimeprazine) Mesoridazine Perazine Periciazine Perphenazine BL-1020 Perphenazine decanoate Perphenazine enanthate Piperacetazine Pipotiazine Pipotiazine palmitate Pipotiazine undecylenate Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes: Chlorprothixene Clopenthixol Clopenthixol decanoate Flupentixol Flupentixol decanoate Tiotixene (thiothixene) Zuclopenthixol Zuclopenthixol acetate Zuclopenthixol decanoate
Disputed	Benzamides: Amisulpride Levosulpiride Nemonapride Remoxipride^‡ Sulpiride Sultopride Tiapride Veralipride^‡ Butyrophenones: Melperone Tricyclics: Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Oxyprothepin decanoate Others: Molindone
Atypical	Benzisoxazole/benzisothiazoles: Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone^# Ziprasidone Butyrophenones: Lumateperone Phenylpiperazines/quinolinones: Aripiprazole Aripiprazole lauroxil Brilaroxazine^† Brexpiprazole Cariprazine Tricyclics: Asenapine Clozapine^# Olanzapine Quetiapine Zotepine Others: Blonanserin Pimavanserin Sertindole
Others	Monoamine-depleting agents: Oxypertine Reserpine Tetrabenazine Others/unknown: Azacyclonol
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Clinical data

Trade names	Elanone-V
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 4-[4-(4-Fluorobenzoyl)piperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
CAS Number	24678-13-5 HCl: 24677-86-9
PubChem CID	32593
ChemSpider	30207
UNII	13P4GX22ES HCl: 96Q0TL6O3G^Y
KEGG	D02668
CompTox Dashboard (EPA)	DTXSID7046120
ECHA InfoCard	100.042.166
Chemical and physical data
Formula	C₂₂H₂₃F₂NO₂
Molar mass	371.428 g·mol⁻¹

Lenperone

See also[]

References[]