Chlorpheniramine Trade names Chlor-trimeton AHFS /Drugs.com Monograph MedlinePlus a682543 Routes of administration Oral ATC code Legal status
(3S )-3-(4-chlorophenyl)-N ,N -dimethyl-3-pyridin-3-ylpropan-1-amine
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.042.779 Formula C 16 H 19 Cl N 2 Molar mass 274.79 g·mol−1 3D model (JSmol )
Clc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
Y Key:SOYKEARSMXGVTM-HNNXBMFYSA-N
Y
Dexchlorpheniramine (trade name Polaramine ) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria .[1] [2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine .
It came into medical use in 1959 and was patented in 1962.[3]
Pharmacology [ ]
Dexchlorpheniramine is an antihistamine , or an antagonist of the histamine H1 receptor . A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]
References [ ]
^ Theunissen, E. L.; Vermeeren, A.; Ramaekers, J. G. (2006). "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance" . British Journal of Clinical Pharmacology . 61 (1): 79–86. doi :10.1111/j.1365-2125.2005.02524.x . PMC 1884990 . PMID 16390354 .
^ Ortíz San Román, L.; Sanavia Morán, E.; Campos Domínguez, M.; Peinador García, M. M. (2013). "Síndrome anticolinérgico por dexclorfeniramina como causa de retención urinaria". Anales de Pediatría . 79 (6): 400–1. doi :10.1016/j.anpedi.2013.02.014 . PMID 23680058 .
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery . John Wiley & Sons. p. 547. ISBN 9783527607495 .
^ Yamamura HI, Snyder SH (1974). "Muscarinic cholinergic binding in rat brain" . Proc. Natl. Acad. Sci. U.S.A . 71 (5): 1725–9. Bibcode :1974PNAS...71.1725Y . doi :10.1073/pnas.71.5.1725 . PMC 388311 . PMID 4151898 .
External links [ ]
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See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors
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See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators