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Setastine
1-[2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]ethyl]azepane
CAS Number PubChem CID ChemSpider UNII Formula C 22 H 28 Cl N O Molar mass −1 3D model (JSmol )
CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN3CCCCCC3
Setastine (Loderix ) is an antihistamine used to treat allergies and rhinitis .[1] [2]
Pharmacology [ ] Pharmacodynamics [ ] Setastine acts as a highly selective H1 receptor antagonist .[3] anticholinergic , antiadrenergic , or antiserotonergic effects.
Pharmacokinetics [ ] Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine .[3]
See also [ ] References [ ]
^ Lantos A; Tóth A; Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica (English Edition) . 39 (1): 22–4. PMID 1677500 . ^ Hirschberg A; Ribári O; Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica (English Edition) . 37 (4): 202–4. PMID 2576575 . ^ a b Porszász J, Varga F, Porszász KG, et al. (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung . 40 (12): 1340–5. PMID 1982751 .
Topical
Sympathomimetics , plainAntiallergic agents,Corticosteroids Other nasal preparations Combination products
Systemic use:Sympathomimetics
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
H1
Agonists Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
H4
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors
Categories :
H1 receptor antagonists Chlorobenzenes Ethers Azepanes Peripherally selective drugs Respiratory system drug stubs Hidden categories:
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