Quifenadine

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Not to be confused with quinidine.
Quifenadine
Quifenadine structure.svg
Clinical data
Trade namesFencarol
Other names3-Quinuclidinyldiphenylmethanol
Routes of
administration		Oral (tablets), IM injection
ATC code
Legal status
Legal status
  • OTC (tablets), ℞-only (solution for IM injection) (RU)
Pharmacokinetic data
Bioavailability45% (Tmax = 1 hour)[1]
MetabolismLiver
Identifiers
  • 1-Azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H23NO
Molar mass293.410 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)(c2ccccc2)C4C3CCN(CC3)C4
  • InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2
  • Key:PZMAHNDJABQWGS-UHFFFAOYSA-N

Quifenadine (Russian: хифенадин, trade name: Phencarol, Фенкарол) is a 2nd generation antihistamine drug, marketed mainly in post-Soviet countries.[2][3] Chemically, it is a quinuclidine derivative.

The drug has antiarrhythmic properties, probably due to the presence of a quinuclidine nucleus in the molecule's core. It acts as a calcium channel blocker and influences the activity of potassium channels.[clarification needed] In children with cardiac arrhythmia, combination therapy with quifenadone and either amiodarone or propafenone was found to be more effective than monotherapy with either amiodarone or propafenone.[4]

Indications[]

  • Allergic rhinitis
  • Acute and chronic urticaria
  • Angioedema
  • Dermatitis
  • Atopic dermatitis
  • Pruritus[1]

References[]

  1. ^ a b "Fencarol (quifenadine) Tablets, for Oral Use. Full Prescribing Information". State Register of Medicines (in Russian). Retrieved 4 January 2016.
  2. ^ "Quifenadine". Drugs.com. Retrieved 28 January 2014.
  3. ^ Makarov L, Balykova L, Soldatova O, Komolyatova V, Serebruany V (2010). "The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: a randomized controlled pilot trial". American Journal of Therapeutics. 17 (4): 396–401. doi:10.1097/MJT.0b013e3181a86987. PMID 19487925.
  4. ^ Солдатова, О.Н.; Балыкова, Л.А.; Макаров, Л.М.; Комолятова, В.Н.; Чупрова, С.Н.; Солдатов, О.М.; Корнилова, Т.И. (2008-09-01). "ЭФФЕКТИВНОСТЬ ФЕНКАРОЛА В СОЧЕТАНИИ С ТРАДИЦИОННЫМИ ПРОТИВОАРИТМИЧЕСКИМИ СРЕДСТВАМИ ПРИ ЭКСТРАСИСТОЛИИ У ДЕТЕЙ". RUDN Journal of Medicine (in Russian) (3): 46–51. ISSN 2313-0245. Archived from the original on 20 November 2020. Retrieved 18 November 2020.
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