Quifenadine
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Trade names | Fencarol |
Other names | 3-Quinuclidinyldiphenylmethanol |
Routes of administration | Oral (tablets), IM injection |
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Bioavailability | 45% (Tmax = 1 hour)[1] |
Metabolism | Liver |
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Formula | C20H23NO |
Molar mass | 293.410 g·mol−1 |
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Quifenadine (Russian: хифенадин, trade name: Phencarol, Фенкарол) is a 2nd generation antihistamine drug, marketed mainly in post-Soviet countries.[2][3] Chemically, it is a quinuclidine derivative.
The drug has antiarrhythmic properties, probably due to the presence of a quinuclidine nucleus in the molecule's core. It acts as a calcium channel blocker and influences the activity of potassium channels.[clarification needed] In children with cardiac arrhythmia, combination therapy with quifenadone and either amiodarone or propafenone was found to be more effective than monotherapy with either amiodarone or propafenone.[4]
Indications[]
- Allergic rhinitis
- Acute and chronic urticaria
- Angioedema
- Dermatitis
- Atopic dermatitis
- Pruritus[1]
References[]
- ^ a b "Fencarol (quifenadine) Tablets, for Oral Use. Full Prescribing Information". State Register of Medicines (in Russian). Retrieved 4 January 2016.
- ^ "Quifenadine". Drugs.com. Retrieved 28 January 2014.
- ^ Makarov L, Balykova L, Soldatova O, Komolyatova V, Serebruany V (2010). "The antiarrhythmic properties of quifenadine, H1-histamine receptor blocker in children with premature beats: a randomized controlled pilot trial". American Journal of Therapeutics. 17 (4): 396–401. doi:10.1097/MJT.0b013e3181a86987. PMID 19487925.
- ^ Солдатова, О.Н.; Балыкова, Л.А.; Макаров, Л.М.; Комолятова, В.Н.; Чупрова, С.Н.; Солдатов, О.М.; Корнилова, Т.И. (2008-09-01). "ЭФФЕКТИВНОСТЬ ФЕНКАРОЛА В СОЧЕТАНИИ С ТРАДИЦИОННЫМИ ПРОТИВОАРИТМИЧЕСКИМИ СРЕДСТВАМИ ПРИ ЭКСТРАСИСТОЛИИ У ДЕТЕЙ". RUDN Journal of Medicine (in Russian) (3): 46–51. ISSN 2313-0245. Archived from the original on 20 November 2020. Retrieved 18 November 2020.
Categories:
- Quinuclidines
- Antihistamines
- Tertiary alcohols
- Russian drugs
- Antiarrhythmic agents
- Respiratory system drug stubs